The biological significance of genomic features is often context-dependent. We present CruzDB, a fast and intuitive programmatic interface to the UCSC genome browser that facilitates integrative analyses of diverse local and remotely hosted datasets. We showcase the syntax of CruzDB using miRNA-binding sites as examples, and further demonstrate its utility with 3 novel biological discoveries. First, we find that while exons replicate early, introns tend to replicate late, suggesting a complex replication pattern in gene regions. Second, variants associated with cognitive functions map to lincRNA transcripts of relevant function. Third, lamina-associated domains are highly enriched in olfaction-related genes. CruzDB is available at https://github.com/brentp/cruzdb
@article{arxiv.1303.3332,
title = {CruzDB: software for annotation of genomic intervals with UCSC genome-browser data},
author = {Brent S Pedersen and Ivana V Yang and Subhajyoti De},
journal= {arXiv preprint arXiv:1303.3332},
year = {2013}
}