English

Comparative analysis of full-field OCT and optical transmission tomography

Optics 2023-10-12 v1 Biological Physics

Abstract

This work compares two tomographic imaging technologies, time-domain full-field optical coherence tomography (FFOCT) working in reflection and optical transmission tomography (OTT), using a new optical setup that combines both. We show that, due to forward-scattering properties, the axial sectioning and contrast in OTT can be optimized by tuning illumination. The influence of sample scattering and thickness are discussed. We illustrate the comparison of the two methods in static (morphology) and dynamic (metabolic contrast) regimes using cell cultures, tissues and entire organisms emphasizing the advantages of both approaches.

Keywords

Cite

@article{arxiv.2307.01888,
  title  = {Comparative analysis of full-field OCT and optical transmission tomography},
  author = {Samer Alhaddad and Olivier Thouvenin and Martine Boccara and Claude Boccara and Viacheslav Mazlin},
  journal= {arXiv preprint arXiv:2307.01888},
  year   = {2023}
}