We present a web interface for the BioFET-SIM program. The web interface allows to conveniently setup calculations based on the BioFET-SIM multiple charges model. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface.
Cite
@article{arxiv.1204.6140,
title = {BioFET-SIM Web Interface: Implementation and Two Applications},
author = {Martin R. Hediger and Jan H. Jensen and Luca De Vico},
journal= {arXiv preprint arXiv:1204.6140},
year = {2013}
}