A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties
Abstract
In this paper we present a method to study the folding structure of a simple model consisting of two kinds of monomers, hydrophobic and hydrophilic. This method has three main steps: an efficient simulation method to bring an open sequence of homopolymer to a folded state, the application of a painting method called (regular hull) to the folded globule and the refolding process of the obtained copolymer sequence. This study allows us to suggest a theoretical function of disorder distribution for copolymer sequences that give rise to a compacted and well micro-phase separated globule.
Keywords
Cite
@article{arxiv.cond-mat/0104440,
title = {A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties},
author = {M-T. Kechadi and R. G. Reilly and K. A. Dawson and Yu. A. Kuznetsov and E. G. Timoshenko},
journal= {arXiv preprint arXiv:cond-mat/0104440},
year = {2007}
}
Comments
11 pages incl. 6 PS figures. Paper presented at the International Conference on Morphology and Kinetics of Phase Separating Complex Fluids, Messina, Italy, June 1997