English

A diploid population model for copy number variation of genetic elements

Probability 2023-02-28 v3 Populations and Evolution

Abstract

We study the following model for a diploid population of constant size NN: Every individual carries a random number of (genetic) elements. Upon a reproduction event each of the two parents passes each element independently with probability 12\tfrac 12 on to the offspring. We study the process XN=(XN(1),XN(2),...)X^N = (X^N(1), X^N(2),...), where XtN(k)X_t^N(k) is the frequency of individuals at time tt that carry kk elements, and prove convergence (in some weak sense) of XNX^N jointly with its empirical first moment ZNZ^N to the ``slow-fast'' system (Z,X)(Z,X), where Xt=Poi(Zt)X_t = \text{Poi}(Z_t) and ZZ evolves according to a critical Feller branching process. We discuss heuristics explaining this finding and some extensions and limitations.

Keywords

Cite

@article{arxiv.2204.11140,
  title  = {A diploid population model for copy number variation of genetic elements},
  author = {Peter Pfaffelhuber and Anton Wakolbinger},
  journal= {arXiv preprint arXiv:2204.11140},
  year   = {2023}
}

Comments

15 pages, 1 figure