Transcriptional delay stabilizes bistable gene networks
Molecular Networks
2015-06-16 v1
Abstract
Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.
Keywords
Cite
@article{arxiv.1305.6365,
title = {Transcriptional delay stabilizes bistable gene networks},
author = {Chinmaya Gupta and José Manuel López and William Ott and Krešimir Josíc and Matthew R. Bennett},
journal= {arXiv preprint arXiv:1305.6365},
year = {2015}
}