The Human Cell Atlas White Paper
Abstract
The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating disease. It will help scientists understand how genetic variants impact disease risk, define drug toxicities, discover better therapies, and advance regenerative medicine. A resource of such ambition and scale should be built in stages, increasing in size, breadth, and resolution as technologies develop and understanding deepens. We will therefore pursue Phase 1 as a suite of flagship projects in key tissues, systems, and organs. We will bring together experts in biology, medicine, genomics, technology development and computation (including data analysis, software engineering, and visualization). We will also need standardized experimental and computational methods that will allow us to compare diverse cell and tissue types - and samples across human communities - in consistent ways, ensuring that the resulting resource is truly global. This document, the first version of the HCA White Paper, was written by experts in the field with feedback and suggestions from the HCA community, gathered during recent international meetings. The White Paper, released at the close of this yearlong planning process, will be a living document that evolves as the HCA community provides additional feedback, as technological and computational advances are made, and as lessons are learned during the construction of the atlas.
Cite
@article{arxiv.1810.05192,
title = {The Human Cell Atlas White Paper},
author = {Aviv Regev and Sarah Teichmann and Orit Rozenblatt-Rosen and Michael Stubbington and Kristin Ardlie and Ido Amit and Paola Arlotta and Gary Bader and Christophe Benoist and Moshe Biton and Bernd Bodenmiller and Benoit Bruneau and Peter Campbell and Mary Carmichael and Piero Carninci and Leslie Castelo-Soccio and Menna Clatworthy and Hans Clevers and Christian Conrad and Roland Eils and Jeremy Freeman and Lars Fugger and Berthold Goettgens and Daniel Graham and Anna Greka and Nir Hacohen and Muzlifah Haniffa and Ingo Helbig and Robert Heuckeroth and Sekar Kathiresan and Seung Kim and Allon Klein and Bartha Knoppers and Arnold Kriegstein and Eric Lander and Jane Lee and Ed Lein and Sten Linnarsson and Evan Macosko and Sonya MacParland and Robert Majovski and Partha Majumder and John Marioni and Ian McGilvray and Miriam Merad and Musa Mhlanga and Shalin Naik and Martijn Nawijn and Garry Nolan and Benedict Paten and Dana Pe'er and Anthony Philippakis and Chris Ponting and Steve Quake and Jayaraj Rajagopal and Nikolaus Rajewsky and Wolf Reik and Jennifer Rood and Kourosh Saeb-Parsy and Herbert Schiller and Steve Scott and Alex Shalek and Ehud Shapiro and Jay Shin and Kenneth Skeldon and Michael Stratton and Jenna Streicher and Henk Stunnenberg and Kai Tan and Deanne Taylor and Adrian Thorogood and Ludovic Vallier and Alexander van Oudenaarden and Fiona Watt and Wilko Weicher and Jonathan Weissman and Andrew Wells and Barbara Wold and Ramnik Xavier and Xiaowei Zhuang and Human Cell Atlas Organizing Committee},
journal= {arXiv preprint arXiv:1810.05192},
year = {2018}
}