Insights, opportunities and challenges provided by large cell atlases
Abstract
The field of single-cell biology is growing rapidly and is generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, and DISCO, allow researchers to access large volumes of curated datasets. Although the majority of the data is from scRNAseq experiments, a wide range of other modalities are represented as well. These resources have created an opportunity to build and expand the computational biology ecosystem to develop tools necessary for data reuse, and for extracting novel biological insights. Here, we highlight achievements made so far, areas where further development is needed, and specific challenges that need to be overcome.
Keywords
Cite
@article{arxiv.2408.06563,
title = {Insights, opportunities and challenges provided by large cell atlases},
author = {Martin Hemberg and Federico Marini and Shila Ghazanfar and Ahmad Al Ajami and Najla Abassi and Benedict Anchang and Bérénice A. Benayoun and Yue Cao and Ken Chen and Yesid Cuesta-Astroz and Zach DeBruine and Calliope A. Dendrou and Iwijn De Vlaminck and Katharina Imkeller and Ilya Korsunsky and Alex R. Lederer and Pieter Meysman and Clint Miller and Kerry Mullan and Uwe Ohler and Nikolaos Patikas and Jonas Schuck and Jacqueline HY Siu and Timothy J. Triche and Alex Tsankov and Sander W. van der Laan and Masanao Yajima and Jean Yang and Fabio Zanini and Ivana Jelic},
journal= {arXiv preprint arXiv:2408.06563},
year = {2024}
}