Superselective adsorption of multivalent polymeric particles
Soft Condensed Matter
2020-12-29 v1
Abstract
Multivalency is a common biological mechanism of formation of strong reversible and selective bonds by grouping weak bonds. Polymers often act as a scaffold to which multiple binding groups are attached. Here I present an analytical theory allowing to calculate avidity and selectivity for multivalent polymeric particles using tools from the theory of associating fluids. I explicitly take into account conformational degrees of freedom of a polymeric scaffold and discuss how they affect superselectivity. I also consider linear polymeric particles with two types of ligands and show that superselectivity does not depend on the sequence of ligands along the backbone for a Gaussian chain with short linkers.
Cite
@article{arxiv.2012.13827,
title = {Superselective adsorption of multivalent polymeric particles},
author = {Elena Patyukova},
journal= {arXiv preprint arXiv:2012.13827},
year = {2020}
}