Structured Models of Cell Migration Incorporating Molecular Binding Processes
Abstract
The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two examples arising from cancer invasion.
Cite
@article{arxiv.1607.05353,
title = {Structured Models of Cell Migration Incorporating Molecular Binding Processes},
author = {Pia Domschke and Dumitru Trucu and Alf Gerisch and Mark A. J. Chaplain},
journal= {arXiv preprint arXiv:1607.05353},
year = {2016}
}