Mathematical Framework for Phylogenetic Birth-And-Death Models
Populations and Evolution
2009-02-06 v1 Genomics
Abstract
A phylogenetic birth-and-death model is a probabilistic graphical model for a so-called phylogenetic profile, i.e., the size distribution for a homolog gene family at the terminal nodes of a phylogeny. Profile datasets are used in bioinformatics analyses for the inference of evolutionary trees, and of functional associations between gene families, as well as for the quantification of various processes guiding genome evolution. Here we describe the mathematical formalism for phylogenetic birth-and-death models. We also present an algorithm for computing the likelihood in a gain-loss-duplication model.
Cite
@article{arxiv.0902.0970,
title = {Mathematical Framework for Phylogenetic Birth-And-Death Models},
author = {Miklós Csűrös and István Miklós},
journal= {arXiv preprint arXiv:0902.0970},
year = {2009}
}