Lambda-prophage induction modeled as a cooperative failure mode of lytic repression
Molecular Networks
2013-05-29 v3 Quantitative Methods
Abstract
We analyze a system-level model for lytic repression of lambda-phage in E. coli using reliability theory, showing that the repressor circuit comprises 4 redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultra-violet radiation are in good agreement with experimental data.
Cite
@article{arxiv.0811.3407,
title = {Lambda-prophage induction modeled as a cooperative failure mode of lytic repression},
author = {Nicholas Chia and Ido Golding and Nigel Goldenfeld},
journal= {arXiv preprint arXiv:0811.3407},
year = {2013}
}
Comments
added reference