Holonomic $\mathcal{D}$-modules of arithmetic type and middle convolution

The aim of the present paper is to study arithmetic properties of $\mathcal{D}$-modules on an algebraic variety over the field of algebraic numbers. We first provide a framework for extending a class of $G$-connections (resp., globally nilpotent connections; resp., almost everywhere nilpotent connections) to holonomic $\mathcal{D}$-modules. It is shown that the derived category of $\mathcal{D}$-modules in each of such extended classes carries a Grothendieck six-functor formalism. This fact leads us to obtain the stability of the middle convolution for $G$-connections with respect to the global inverse radii. As a consequence of our study of middle convolution, we prove equivalences between various arithmetic properties on rigid Fuchsian systems. This result gives, for such systems of differential equations, an affirmative answer to a conjecture described in a paper written by Y. Andr\'{e} and F. Baldassarri.