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How the very first nervous systems evolved remains a fundamental open question. Molecular and genomic techniques have revolutionized our knowledge of the molecular ingredients behind this transition but not yet provided a clear picture of…

Neurons and Cognition · Quantitative Biology 2017-10-31 Ronald A. J. van Elburg , Oltman O. de Wiljes , Michael Biehl , Fred A. Keijzer

A double-stranded DNA unravels thermally through intermediate denatured bubble segments. Intrinsically, fluctuations ensue at the bubble boundaries from non-equilibrium (NE) energy exchanges with the environment. However, such details gets…

Soft Condensed Matter · Physics 2018-09-21 Keren Jiang , Faheem Khan , Javix Thomas , Arindam Phani , Thomas Thundat

Neuromorphic computing uses brain-inspired principles to design circuits that can perform computational tasks with superior power efficiency to conventional computers. Approaches that use traditional electronic devices to create artificial…

Applied Physics · Physics 2020-07-14 J. Grollier , D. Querlioz , K. Y. Camsari , K. Everschor-Sitte , S. Fukami , M. D. Stiles

Memristive circuit elements constitute a cornerstone for novel electronic applications, such as neuromorphic computing, called to revolutionize information technologies. By definition, memristors are sensitive to the history of electrical…

In the usual quantum tunneling, a low-energy quantum particle penetrates across a physical barrier of higher potential energy, by traversing a classically forbidden region, and finally escapes into another region. In an analogous scenario,…

Quantum Physics · Physics 2025-08-11 V. R. Krithika , M. S. Santhanam , T. S. Mahesh

Neural activity patterns related to behavior occur at many scales in time and space from the atomic and molecular to the whole brain. Here we explore the feasibility of interpreting neurophysiological data in the context of many-body…

Other Quantitative Biology · Quantitative Biology 2009-11-11 Walter J. Freeman , Giuseppe Vitiello

Electrical neural signalling typically takes place at the time-scale of milliseconds, and is typically modeled using the cable equation. This is a good approximation for processes when ionic concentrations vary little during the time course…

Cell Behavior · Quantitative Biology 2014-03-05 Geir Halnes , Ivar Østby , Klas H. Pettersen , Stig W. Omholt , Gaute T. Einevoll

What visual information is encoded in individual brain regions, and how do distributed patterns combine to create their neural representations? Prior work has used generative models to replicate known category selectivity in isolated…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Haomiao Chen , Keith W Jamison , Mert R. Sabuncu , Amy Kuceyeski

The proper functioning of the nervous system depends critically on the intricate network of synaptic connections that are generated during the system development. During the network formation, the growth cones migrate through the embryonic…

Disordered Systems and Neural Networks · Physics 2007-05-23 Ronen Segev , Eshel Ben-Jacob

Models of the mind are based on the possibility of computing in brain microtubules. From this point of view, information processing is the fundamental issue for understanding the brain mechanisms that produce consciousness. The cytoskeleton…

Subcellular Processes · Quantitative Biology 2007-05-23 Jean Faber , Renato Portugal , Luiz Pinguelli Rosa

Neuronal networks are controlled by a combination of the dynamics of individual neurons and the connectivity of the network that links them together. We study a minimal model of the preBotzinger complex, a small neuronal network that…

Neurons and Cognition · Quantitative Biology 2013-05-29 David J. Schwab , Robijn F. Bruinsma , Alex J. Levine

Local networks of neurons are nonlinear systems driven by synaptic currents elicited by its own spiking activity and the input received from other brain areas. Synaptic currents are well approximated by correlated Gaussian noise. Besides,…

Neurons and Cognition · Quantitative Biology 2024-04-09 Gianni Valerio Vinci , Maurizio Mattia

Here we describe an "information based exchange" model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the…

Neurons and Cognition · Quantitative Biology 2015-09-17 James Kozloski

Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence…

Neurons and Cognition · Quantitative Biology 2015-10-30 John D. Medaglia , Theodore D. Satterthwaite , Tyler M. Moore , Kosha Ruparel , Ruben C. Gur , Raquel E. Gur , Danielle S. Bassett

Based on a biophysical model of retinal Starburst Amacrine Cell (SAC) \cite{karvouniari-gil-etal:19} we analyse here the dynamics of retinal waves, arising during the visual system development. Waves are induced by spontaneous bursting of…

Neurons and Cognition · Quantitative Biology 2019-12-10 Dora Matzakos-Karvouniari , Bruno Cessac , L. Gil

We begin by demonstrating that the neuronal state equation from Dynamic Causal Modelling takes on the form of the discretized Fokker-Planck equation upon the inclusion of local activity gradients within a network. Using the Jacobian of this…

Quantitative Methods · Quantitative Biology 2019-11-27 Erik D. Fagerholm , Rosalyn J. Moran , Robert Leech

Despite the prevalent view that quantum mechanics is irrelevant to macroscopic biological systems because of inherent noise and decoherence, this paper demonstrates that the electrical noise (Brownian motion) in neuron membranes gives rise…

Neurons and Cognition · Quantitative Biology 2024-08-22 Partha Ghose

One of the central aims of neuroscience is to reliably predict the behavioral response of an organism using its neural activity. If possible, this implies we can causally manipulate the neural response and design brain-computer-interface…

Neurons and Cognition · Quantitative Biology 2025-04-01 Jayanth R Taranath

We consider a stochastic version of an excitable system based on the Morris-Lecar model of a neuron, in which the noise originates from stochastic Sodium and Potassium ion channels opening and closing. One can analyze neural excitability in…

Neurons and Cognition · Quantitative Biology 2015-06-15 Jay M. Newby , Paul C. Bressloff , James P. Keener

Understanding the basic operational logics of the nervous system is essential to advancing neuroscientific research. However, theoretical efforts to tackle this fundamental problem are lacking, despite the abundant empirical data about the…

Neurons and Cognition · Quantitative Biology 2021-09-07 Cheng Qian