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Neuromorphic networks of artificial neurons and synapses can solve computational hard problems with energy efficiencies unattainable for von Neumann architectures. For image processing, silicon neuromorphic processors outperform graphic…

Emerging Technologies · Computer Science 2018-11-08 Wei Yi , Kenneth K. Tsang , Stephen K. Lam , Xiwei Bai , Jack A. Crowell , Elias A. Flores

In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are…

Biological Physics · Physics 2009-11-13 Bindu S. Govindan , Manoj Gopalakrishnan , Debashish Chowdhury

Physical systems exhibiting neuromechanical functions promise to enable structures with directly encoded autonomy and intelligence. We report on a class of neuromorphic metamaterials embodying bioinspired mechanosensing, memory, and…

Nucleic acids and proteins are not only biologically important polymers: They have recently been recognized as novel functional materials surpassing in many aspects the conventional ones. Although Herculean efforts have been undertaken to…

Soft Condensed Matter · Physics 2010-06-17 Waleed Shinwari , Jamal Deen , Evgeni Starikov , Gianaurelio Cuniberti

Photonic neural networks benefit from both the high channel capacity- and the wave nature of light acting as an effective weighting mechanism through linear optics. The neuron's activation function, however, requires nonlinearity which can…

Molecular communication (MC) is an emerging paradigm that takes inspiration from biological processes, enabling communication at the nanoscale and facilitating the development of the Internet of Bio-Nano Things (IoBNT). Traditional models…

Emerging Technologies · Computer Science 2025-01-22 Shaojie Zhang , Ozgur B. Akan

Memory cells are an important building block of digital electronics. We combine here the unique electronic properties of semiconducting monolayer MoS2 with the high conductivity of graphene to build a 2D heterostructure capable of…

Mesoscale and Nanoscale Physics · Physics 2013-03-21 Simone Bertolazzi , Daria Krasnozhon , Andras Kis

Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical…

Biomolecules · Quantitative Biology 2009-11-05 Ashok Palaniappan , Eric Jakobsson

Synaptic plasticity, the dynamic tuning of signal transmission strength between neurons, serves as a fundamental basis for memory and learning in biological organisms. This adaptive nature of synapses is considered one of the key features…

Mesoscale and Nanoscale Physics · Physics 2024-11-11 Yechan Noh , Alex Smolyanitsky

The bipolar organization of the microtubule-based mitotic spindle is essential for the faithful segregation of chromosomes in cell division. Despite our extensive knowledge of genes and proteins, the physical mechanism of how the ensemble…

Biological Physics · Physics 2022-11-02 Lucan Yan , Tatsuya Fukuyama , Megumi Yamaoka , Yusuke T. Maeda , Yuta Shimamoto

Bio-integrated neuromorphic systems promise for new protocols to record and regulate the signaling of biological systems. Making such artificial neural circuits successful requires minimal circuit complexity and ion-based operating…

Motor-driven cytoskeletal remodeling in cellular systems can often be accompanied by a diffusive-like effect at local scales, but distinguishing the contributions of the ordering process, such as active contraction of a network, from this…

Biological Physics · Physics 2024-08-22 Soichi Hirokawa , Heun Jin Lee , Rachel A Banks , Ana I Duarte , Bibi Najma , Matt Thomson , Rob Phillips

Mixtures of microtubules and molecular motors form active materials with diverse dynamical behaviors that vary based on their constituents' molecular properties. We map the non-equilibrium phase diagram of microtubules and tip-accumulating…

Soft Condensed Matter · Physics 2021-08-04 Bezia Lemma , Noah P. Mitchell , Radhika Subramanian , Daniel J. Needleman , Zvonimir Dogic

Advanced neural interfaces mediate a bio-electronic link between the nervous system and microelectronic devices, bearing great potential as innovative therapy for various diseases. Spikes from a large number of neurons are recorded leading…

Emerging Technologies · Computer Science 2016-11-30 Isha Gupta , Alexantrou Serb , Ali Khiat , Ralf Zeitler , Stefano Vassanelli , Themistoklis Prodromakis

Activity and renewability are distinctive features of living matter, and constitute a new class of materials that we term renewable active matter. A striking example is the cell cytoskeleton, where myosin filaments bind to the actin…

Soft Condensed Matter · Physics 2025-05-27 M. Abhishek , Ankit Dhanuka , Deb Sankar Banerjee , Madan Rao

An aster of microtubules is a set of flexible polar filaments with dynamic plus-ends, which irradiate from a common location at which the minus ends of the filaments are found. Processive soluble oligomeric motor complexes can bind…

Soft Condensed Matter · Physics 2007-05-23 Francois Nedelec

Brain-inspired computing architectures attempt to emulate the computations performed in the neurons and the synapses in human brain. Memristors with continuously tunable resistances are ideal building blocks for artificial synapses. Through…

The ever-increasing amount of data from ubiquitous smart devices fosters data-centric and cognitive algorithms. Traditional digital computer systems have separate logic and memory units, resulting in a huge delay and energy cost for…

Applied Physics · Physics 2025-03-17 Qiming Shao , Zhongrui Wang , Yan Zhou , Shunsuke Fukami , Damien Querlioz , Leon O. Chua

Late long-term potentiation (L-LTP) appears essential for the formation of long-term memory, with memories at least partly encoded by patterns of strengthened synapses. How memories are preserved for months or years, despite molecular…

Neurons and Cognition · Quantitative Biology 2015-05-13 Paul Smolen

A programmable linear resistor with a compact footprint would have profound implications for microelectronics, enabling efficient in-sensor analog signal processing and in-memory computing. Non-volatile memory offers a potential solution…