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Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

Neuromorphic photonics relies on efficiently emulating analog neural networks at high speeds. Prior work showed that transducing signals from the optical to the electrical domain and back with transimpedance gain was an efficient approach…

Microtubules are an essential physical building block of cellular systems. They are organized using specific crosslinkers, motors, and influencers of nucleation and growth. With the addition of anti-parallel crosslinkers, microtubule…

Biological Physics · Physics 2021-06-23 Sumon Sahu , Lena Herbst , Ryan Quinn , Jennifer L. Ross

DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using…

Biological Physics · Physics 2013-01-01 Ajeet K. Sharma , Debashish Chowdhury

The cytoskeleton is essential for the maintenance of cell morphology in eukaryotes. In fission yeast for example, polarized growth sites are organized by actin whereas microtubules (MT) acting upstream control where growth occurs (La…

Cell Behavior · Quantitative Biology 2009-03-30 Dietrich Foethke , Tatyana Makushok , Damian Brunner , Francois Nedelec

An analytical function is derived that exactly describes the amplification process due to a series of discrete, Poisson-like amplifications like those in a photo multiplier tube (PMT). A numerical recipe is provided that implements this…

Instrumentation and Detectors · Physics 2007-05-23 Jonas Rademacker

We here present a model of nonlinear dynamics of microtubules (MT) in the context of modified extended tanh-function (METHF) method. We rely on the ferroelectric model of MTs published earlier by Satari\'c et al [1] where the motion of MT…

Dream of developing molecule-based logic and memory device is more than 70-year-old. Presently, molecule-based devices are also considered for quantum computation hardware. The recent studies have shown the molecule connected to metal leads…

Materials Science · Physics 2019-12-04 Pawan Tyagi , Edwards Friebe , Collin Baker

A common type of cytoskeletal morphology involves multiple converging microbutubules with their minus ends collected and stabilized by a microtubule organizing center (MTOC) in the interior of the cell. This arrangement enables the…

Cell Behavior · Quantitative Biology 2023-01-04 Niranjan Sarpangala , Brooke Randell , Ajay Gopinathan , Oleg Kogan

A new type of diode that is made entirely of electrically excitable muscle cells and nonexcitable fibroblast cells is designed, fabricated, and characterized. These two cell types in a rectangular pattern allow the signal initiated on the…

Tissues and Organs · Quantitative Biology 2017-06-02 Uryan Isik Can , Neerajha Nagarajan , Dervis Can Vural , Pinar Zorlutuna

Electro-optic modulation performs a technological relevant functionality such as for communication, beam steering, or neuromorphic computing through providing the nonlinear activation function of a perceptron. Wile Silicon photonics enabled…

Memristors are resistive elements retaining information of their past dynamics. They have garnered substantial interest due to their potential for representing a paradigm change in electronics, information processing and unconventional…

Quantum Physics · Physics 2017-02-17 J. Salmilehto , F. Deppe , M. Di Ventra , M. Sanz , E. Solano

Cytoskeletal networks are foundational examples of active matter and central to self-organized structures in the cell. In vivo, these networks are active and heavily crosslinked. Relating their large-scale dynamics to properties of their…

Information processing in the mammalian brain relies on a careful regulation of the membrane potential dynamics of its constituent neurons, which propagates across the neuronal tissue via electrical signalling. We recently reported the…

Neurons and Cognition · Quantitative Biology 2019-02-19 Rosa Martinez-Corral , Jintao Liu , Arthur Prindle , Gurol M. Suel , Jordi Garcia-Ojalvo

We present a systematic study of the influence of cell geometry on the orientational distribution of microtubules (MTs) nucleated from a single microtubule organizing center (MTOC). For simplicity we consider an elliptical cell geometry, a…

Biomolecules · Quantitative Biology 2022-11-30 Panayiotis Foteinopoulos , Bela M. Mulder

The classic three-terminal electronic transistors and the emerging two-terminal ion-based memristors are complementary to each other in various nonconventional information processing systems in a heterogeneous integration approach, such as…

Applied Physics · Physics 2023-01-06 Yifei Yang , Lujie Xu , Mingkun Xu , Huan Liu , Dameng Liu , Wenrui Duan , Jing Pei , Huanglong Li

Neuromorphic computing --- brainlike computing in hardware --- typically requires myriad CMOS spiking neurons interconnected by a dense mesh of nanoscale plastic synapses. Memristors are frequently citepd as strong synapse candidates due to…

Neural and Evolutionary Computing · Computer Science 2015-09-02 David Howard , Larry Bull , Ben De Lacy Costello

We study exciton quantum transfer along a molecular chain whilst accounting for the effects of permanent dipoles that are induced by charge displacements in the molecular orbitals. These effects are typically neglected as they do not arise…

Chemical Physics · Physics 2025-01-14 Adam Burgess , Erik Gauger

Fluid and ionic transport at nanoscale recently highlighted a wealth of exotic behaviours. However, the artificial nanofluidic devices are still far from the advanced functionalities existing in biological systems, such as electrically and…

Mesoscale and Nanoscale Physics · Physics 2020-11-13 Alice Marcotte , Timothée Mouterde , Antoine Niguès , Alessandro Siria , Lydéric Bocquet

Control of the cytoskeleton and mechanical contacts with the extracellular environment are essential component of motility in eukaryotic cells. In the absence of signals, cells continuously rebuild the cytoskeleton and periodically extend…

Cell Behavior · Quantitative Biology 2013-09-27 Varunyu Khamviwath , Hans G. Othmer