Related papers: Shock waves in virus fitness evolution
We develop a stochastic framework for viral population dynamics at the cellular level that explicitly incorporates the replication cycle with random stage durations. The model is formulated as a structured birth-death process coupled with a…
This paper analyzes a simplified model of viral infection and evolution using the 'grand canonical ensemble' and formalisms from statistical mechanics and thermodynamics to enumerate all possible viruses and to derive thermodynamic…
Darwinian evolution can be modeled in general terms as a flow in the space of fitness (i.e. reproductive rate) distributions. In the diffusion approximation, Tsimring et al. have showed that this flow admits "fitness wave" solutions:…
We study the survival probability of moving relativistic unstable particles with definite momentum $\vec{p} \neq 0$. The amplitude of the survival probability of these particles is calculated using its integral representation. We found…
The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In…
Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mutational loads and reduced fitness. It remains unclear how…
We consider a general class of Markovian models describing the growth in a randomly fluctuating environment of a clonal biological population having several phenotypes related by stochastic switching. Phenotypes differ e.g. by the level of…
We consider evolution of wave pulses with formation of dispersive shock waves in framework of fully nonlinear shallow-water equations. Situations of initial elevations or initial dips on the water surface are treated and motion of the…
We consider an exponentially growing population of cells undergoing mutations and ask about the effect of reproductive fluctuations (genetic drift) on its long-term evolution. We combine first step analysis with the stochastic dynamics of a…
We study closed systems of particles that are subject to stochastic forces in addition to the conservative forces. The stochastic equations of motion are set up in such a way that the energy is strictly conserved at all times. To ensure…
A parameter estimation problem for a class of semilinear stochastic evolution equations is considered. Conditions for consistency and asymptotic normality are given in terms of growth and continuity properties of the nonlinear part.…
A pipeline to evaluate the evolution of viral dynamics based on a new model-driven approach has been developed in the present study. The proposed methods exploit real data and the multiscale structure of the infection dynamics to provide…
A mechanism is proposed for the growth of vesicles dispersed in a liquid solvent and a size distribution function is obtained for the vesicles, both from the first principles calculations. This distribution function is shown to be…
We analyze the time evolution of simple nuclear rotational wave packets (WP) called circular, linear or elliptic, depending on squeezing parameter $\eta$, assuming that $E=\hbar\omega_0 I(I+1)$. The scenario of fractional revivals found by…
We investigate the profound relation between the equations of biological evolution and quantum mechanics by writing a biologically inspired equation for the stochastic dynamics of an ensemble of particles. Interesting behavior is observed…
We consider a class of non-local reaction-diffusion problems, referred to as replicator-mutator equations in evolutionary genetics. For a confining fitness function, we prove well-posedness and write the solution explicitly, via some…
We construct a pathwise formulation for a multi-type age-structured population dynamics, which involves an age-dependent cell replication and transition of gene- or phenotypes. By employing the formulation, we derive a variational…
The symmetric distribution and all other states in the symmetry sector of the frequency trajectory increase mean fitness during competitive replication at sublinear propagation rates (parabolic time course). States in the non-symmetry…
The replicator-mutator equation is a model for populations of individuals carrying different traits, with a fitness function mediating their ability to replicate, and a stochastic model for mutation. We derive analytical solutions for the…
We discuss the behaviour of the Larmor frequency shift and the longitudinal relaxation rate due to non-uniform electromagnetic fields on an assembly of spin 1/2 particles, in adiabatic and nonadiabatic regimes. We also show some general…