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Experiments were performed to test the effect of an electric field on growing E-coli cultures. Cell growing dishes were fitted with platinum wires to create a potential drop across the dish. Water diluted E-coli cultures were brushed across…

Biological Physics · Physics 2017-09-11 Eshel Faraggi

Observations of single epidermal cells on flat adhesive substrates have revealed two distinct morphological and functional states, namely a non-migrating symmetric unpolarized state and a migrating asymmetric polarized state. These states…

Biological Physics · Physics 2010-04-14 Wolfgang Alt , Martin Bock , Christoph Möhl

We demonstrate a method of concentrating and patterning of biological cells on a chip, exploiting the confluence of electric and thermal fields, without necessitating the use of any external heating or illuminating source. The technique…

Biological Physics · Physics 2019-05-16 Golak Kunti , Tarun Agarwal , Anandaroop Bhattacharya , Tapas Kumar Maiti , Suman Chakraborty

Chemotactic cells establish cell polarity in the absence of external guidance cues. Such self-organized polarity is induced by spontaneous symmetry breaking in the intracellular activities, which produces an emergent memory effect…

Cell Behavior · Quantitative Biology 2015-06-16 Tetsuya Hiraiwa , Akihiro Nagamatsu , Naohiro Akuzawa , Masatoshi Nishikawa , Tatsuo Shibata

The dynamics of growth of bacterial populations has been extensively studied for planktonic cells in well-agitated liquid culture, in which all cells have equal access to nutrients. In the real world, bacteria are more likely to live in…

Populations and Evolution · Quantitative Biology 2017-11-01 Xinxian Shao , Andrew Mugler , Justin Kim , Ha Jun Jeong , Bruce Levin , Ilya Nemenman

The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the…

Biological Physics · Physics 2023-02-08 Zitao Yang , Elena F. Koslover

We investigate general aspects of molecular line formation under conditions which are typical of prestellar cores. Focusing on simple linear molecules, we study formation of their rotational lines by radiative transfer simulations. We…

Astrophysics · Physics 2009-11-13 Ya. Pavlyuchenkov , D. Wiebe , B. Shustov , Th. Henning , R. Launhardt , D. Semenov

The dielectric behavior of a linear cluster of two or more living cells connected by tight junctions is analyzed using a spectral method. The polarizability of this system is obtained as an expansion over the eigenmodes of the linear…

Biological Physics · Physics 2010-02-12 Titus Sandu , Daniel Vrinceanu , Eugen Gheorghiu

We demonstrate 'differential dynamic microscopy' (DDM) for the fast, high throughput characterization of the dynamics of active particles. Specifically, we characterize the swimming speed distribution and the fraction of motile cells in…

Quantitative Methods · Quantitative Biology 2011-07-12 Laurence G. Wilson , Vincent A. Martinez , Jana Schwarz-Linek , J. Tailleur , Peter N. Pusey , Gary Bryant , Wilson C. K. Poon

A biophysical model of epimorphic regeneration based on a continuum percolation process of fully penetrable disks in two dimensions is proposed. All cells within a randomly chosen disk of the regenerating organism are assumed to receive a…

Biological Physics · Physics 2023-11-06 Vladimir García-Morales

Despite the absence of a membrane-enclosed nucleus, the bacterial DNA is typically condensed into a compact body - the nucleoid. This compaction influences the localization and dynamics of many cellular processes including transcription,…

We investigate the linear stability analysis of a pathway-based diffusion model (PBDM), which characterizes the dynamics of the engineered Escherichia coli populations [X. Xue and C. Xue and M. Tang, P LoS Computational Biology, 14 (2018),…

Numerical Analysis · Mathematics 2023-04-03 Yaming Zhang , Ning Jiang , Jiangyan Liang , Yi-Long Luo , Min Tang

Various molecules exclusively accumulate at the front or back of migrating eukaryotic cells in response to a shallow gradient of extracellular signals. Directional sensing and signal amplification highlight the essential properties in the…

Cell Behavior · Quantitative Biology 2015-06-26 Mikiya Otsuji , Shuji Ishihara , Carl Co , Kozo Kaibuchi , Atsushi Mochizuki , Shinya Kuroda

We consider an initial-boundary value problem describing the formation of colony patterns of bacteria Escherichia coli. This model consists of reaction-diffusion equations coupled with the Keller-Segel system from the chemotaxis theory in a…

Analysis of PDEs · Mathematics 2021-01-08 Rafał Celiński , Danielle Hilhorst , Grzegorz Karch , Masayasu Mimura , Pierre Roux

Random lateral translocation of lipids and proteins is a universal process on membrane surfaces. Local aggregation or organization of lipids and proteins can be induced when this lateral random diffusion is mediated by the electrostatic…

Quantitative Methods · Quantitative Biology 2015-06-03 Y. C. Zhou

It has recently been reported that bacteria, such as E.coli and P. putida, perform distinct modes of motion when placed in porous media as compared to dilute regions or free space. This has led us to suggest an efficient strategy for active…

Soft Condensed Matter · Physics 2022-04-12 Ehsan Irani , Zahra Mokhtari , Annette Zippelius

Single-layer atom or vacancy clusters in the presence of electromigration are studied theoretically assuming an isotropic medium. A variety of distinctive behaviors distinguish the response in the three standard limiting cases of periphery…

Materials Science · Physics 2009-10-31 O. Pierre-Louis , T. L. Einstein

Cell polarization is a critical process that separates molecular species into two distinct regions in prokaryotic and eukaryotic cells, guiding biological processes such as cell division and cell differentiation. Although several underlying…

Molecular Networks · Quantitative Biology 2025-01-28 Yixuan Chen , Guoye Guan , Lei-Han Tang , Chao Tang

The Min proteins from Escherichia coli can self-organize into traveling waves on supported lipid bilayers. In Proc. Natl. Acad. Sci. USA 109, 15283 (2012) we showed that these waves are guided along the boundaries of membrane patches. We…

Subcellular Processes · Quantitative Biology 2014-06-06 Mike Bonny , Jakob Schweizer , Martin Loose , Ingolf Mönch , Petra Schwille , Karsten Kruse

The process of polarization determines the head and tail of single cells. A mechanism of this kind frequently precedes the subsequent cell locomotion and it determines the direction of motion. The process of polarization has frequently been…

Biological Physics · Physics 2021-12-30 Eduardo Moreno , Sergio Alonso