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We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Deciphering complex gene-gene interactions remains challenging in transcriptomics as traditional methods often miss higher-order and nonlinear dependencies. This study introduces a quantum-inspired framework leveraging tensor networks (TNs)…

Molecular Networks · Quantitative Biology 2025-09-09 Olatz Sanz Larrarte , Borja Aizpurua , Reza Dastbasteh , Ruben M. Otxoa , Josu Etxezarreta Martinez

Being able to design genetic regulatory networks (GRNs) to achieve a desired cellular function is one of the main goals of synthetic biology. However, determining minimal GRNs that produce desired time-series behaviors is non-trivial. In…

Computational Engineering, Finance, and Science · Computer Science 2022-01-24 Javier Garcia-Bernardo , Margaret J. Eppstein

The degree distribution of a real world network -- the number of links per node -- often follows a power law, with some hubs having many more links than traditional graph generation methods predict. For years, preferential attachment and…

Social and Information Networks · Computer Science 2024-09-30 Josh Johnston , Tim Andersen

In a recursive way and by including a parameter, we introduce a family of deterministic scale-free networks. The resulting networks exhibit small-world effects. We calculate the exact results for the degree exponent, the clustering…

Statistical Mechanics · Physics 2007-05-23 Zhongzhi Zhang , Lili Rong

Random network models play a prominent role in modeling, analyzing and understanding complex phenomena on real-life networks. However, a key property of networks is often neglected: many real-world networks exhibit spatial structure, the…

Quantitative Methods · Quantitative Biology 2017-02-07 John Lang , Hans De Sterck , Jamieson L. Kaiser , Joel C. Miller

A random network is grown by introducing at unit rate randomly selected nodes on the Euclidean space. A node is randomly connected to its $i$-th predecessor of degree $k_i$ with a directed link of length $\ell$ using a probability…

Statistical Mechanics · Physics 2009-11-07 S. S. Manna , Parongama Sen

We use the configuration model to generate networks having a degree distribution that follows a $q$-exponential, $P_q(k)=(2-q)\lambda[1-(1-q)\lambda k]^{1/(q-1)}$, for arbitrary values of the parameters $q$ and $\lambda$. We study the…

In this work, we present a quantum circuit model for inferring gene regulatory networks (GRNs). The model is based on the idea of using qubit-qubit entanglement to simulate interactions between genes. We provide preliminary results that…

Emerging Technologies · Computer Science 2022-07-06 Cristhian Roman-Vicharra , James J. Cai

Textual analysis of typical microbial genomes reveals that they have the statistical characteristics of a DNA sequence of a much shorter length. This peculiar property supports an evolutionary model in which a genome evolves by random…

Biological Physics · Physics 2009-11-07 L. C. Hsieh , L. F. Luo , F. M. Ji , H. C. Lee

We apply random matrix theory to complex networks. We show that nearest neighbor spacing distribution of the eigenvalues of the adjacency matrices of various model networks, namely scale-free, small-world and random networks follow…

Adaptation and Self-Organizing Systems · Physics 2016-09-08 Jayendra N. Bandyopadhyay , Sarika Jalan

A large computer program is typically divided into many hundreds or even thousands of smaller units, whose logical connections define a network in a natural way. This network reflects the internal structure of the program, and defines the…

Disordered Systems and Neural Networks · Physics 2009-11-10 Alessandro P. S. de Moura , Ying-Cheng Lai , Adilson E. Motter

We investigate the equilibration of a small isolated quantum system by means of its matrix of asymptotic transition probabilities in a preferential basis. The trace of this matrix is shown to measure the degree of equilibration of the…

Statistical Mechanics · Physics 2016-02-04 J. M. Luck

Genetic regulatory networks (GRNs) have been widely studied, yet there is a lack of understanding with regards to the final size and properties of these networks, mainly due to no network currently being complete. In this study, we analyzed…

Molecular Networks · Quantitative Biology 2019-03-13 Adrian I. Campos-González , Julio A. Freyre-González

Bayesian Likelihood-Free Inference methods yield posterior approximations for simulator models with intractable likelihood. Recently, many works trained neural networks to approximate either the intractable likelihood or the posterior…

Computation · Statistics 2022-06-01 Lorenzo Pacchiardi , Ritabrata Dutta

The Ising model on a $restricted$ scale-free network (SFN) has been studied employing Monte Carlo simulations. This network is described by a power-law degree distribution in the form $P(k)~k^{-\alpha}$, and is called restricted, because…

Statistical Mechanics · Physics 2023-05-24 R. A. Dumer , M. Godoy

We study the traffic-driven epidemic spreading on scale-free networks with tunable degree distribution. The heterogeneity of networks is controlled by the exponent $\gamma$ of power-law degree distribution. It is found that the epidemic…

Physics and Society · Physics 2018-02-14 Han-Xin Yang , Bing-Hong Wang

We study the statistical behavior under random sequential renormalization(RSR) of several network models including Erd"os R'enyi (ER) graphs, scale-free networks and an annealed model (AM) related to ER graphs. In RSR the network is locally…

Statistical Mechanics · Physics 2011-12-22 Golnoosh Bizhani , Peter Grassberger , Maya Paczuski

In general, the power-law degree distribution has profound influence on various dynamical processes defined on scale-free networks. In this paper, we will show that power-law degree distribution alone does not suffice to characterize the…

Statistical Mechanics · Physics 2009-12-09 Zhongzhi Zhang , Weilen Xie , Shuigeng Zhou , Mo Li , Jihong Guan

A large number of complex networks, both natural and artificial, share the presence of highly heterogeneous, scale-free degree distributions. A few mechanisms for the emergence of such patterns have been suggested, optimization not being…

Statistical Mechanics · Physics 2009-11-07 S. Valverde , R. Ferrer i Cancho , R. V. Sole
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