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The phase transition of $(PolyA/PolyT)_{100}$ duplex into the denaturated state is studied in the Peyrard-Bishop-Dauxois model by the method of direct molecular-dynamical modeling. The temperature dependencies of the total energy and heat…

Soft Condensed Matter · Physics 2020-02-04 I. V. Likhachev , V. D. Lakhno

The onset of intermediate states (denaturation bubbles) and their role during the melting transition of DNA are studied using the Peyrard-Bishop-Daxuois model by Monte Carlo simulations with no adjustable parameters. Comparison is made with…

Statistical Mechanics · Physics 2009-11-10 S. Ares , N. K. Voulgarakis , K. O. Rasmussen , A. R. Bishop

We investigate the nonlinear dynamics of a damped Peyrard-Bishop DNA model taking into account long-range interactions with distance dependence |l|^-s on the elastic coupling constant between different DNA base pairs. Considering both…

Biological Physics · Physics 2017-07-12 J. Brizar Okaly , Alain Mvogo , R. Laure Woulaché , T. Crépin Kofané

We propose a new simple model for DNA denaturation bases on the pendulum model of Englander\cite{A1} and the microscopic model of Peyrard {\it et al.},\cite{A3} so called "combined model". The main parameters of our model are: the coupling…

Biological Physics · Physics 2007-08-23 D. L. Hien , N. T. Nhan , V. Thanh Ngo , N. A. Viet

The melting behavior of long, heterogeneous DNA chains is examined within the framework of the nonlinear lattice dynamics based Peyrard-Bishop-Dauxois (PBD) model. Data for the pBR322 plasmid and the complete T7 phage have been used to…

Biological Physics · Physics 2012-02-20 Nikos Theodorakopoulos

Tethered particle motion experiments are versatile single-molecule techniques enabling one to address in vitro the molecular properties of DNA and its interactions with various partners involved in genetic regulations. These techniques…

Biological Physics · Physics 2019-09-05 Manoel Manghi , Nicolas Destainville , Annaël Brunet

We study the effects of the shear force on the rupture mechanism on a double stranded DNA. Motivated by recent experiments, we perform the atomistic simulations with explicit solvent to obtain the distributions of extension in hydrogen and…

Soft Condensed Matter · Physics 2015-06-17 S. Nath , T. Modi , R. K. Mishra , D. Giri , B. P. Mandal , S. Kumar

We report on the nature of the thermal denaturation transition of homogeneous DNA as determined from a renormalisation group analysis of the Peyrard-Bishop-Dauxois model. Our approach is based on an analogy with the phenomenon of critical…

Statistical Mechanics · Physics 2015-05-18 Jose Manuel Romero-Enrique , Francisco de los Santos , Miguel A. Munoz

DNA denaturation has long been a subject of intense study due to its relationship to DNA transcription and its fundamental importance as a nonlinear, structural transition. Many aspects of this phenomenon, however, remain poorly understood.…

Mesoscale and Nanoscale Physics · Physics 2011-06-16 Kirill A. Velizhanin , Chih-Chun Chien , Yonatan Dubi , Michael Zwolak

A phenomenological model based on the three-dimensional theory of nonlinear elasticity is developed to describe the phenomenon of overstretching in the force-extension curve for dsDNA. By using the concept of a material with multiple…

Biomolecules · Quantitative Biology 2008-02-25 Ray W. Ogden , Giuseppe Saccomandi , Ivonne Sgura

In this paper we provide an alternative approach to the works of the physicists S. Cocco and R. Monasson about a model of DNA molecules. The aim is to predict the sequence of bases by mechanical stimulations. The model described by the…

Applications · Statistics 2012-02-10 Pierre Andreoletti , Roland Diel

The impact of damping effect and external forces to the DNA breathing is investigated within the Peyrard-Bishop model. In in the continuum limit, the dynamics of the breathing of DNA is described by the forced-damped nonlinear Schrodinger…

Biological Physics · Physics 2012-08-14 A. Sulaiman , F. P. Zen , H. Alatas , L. T. Handoko

In this paper, we show that the coarse grain model for DNA, which has been proposed recently by Knotts, Rathore, Schwartz and de Pablo (J. Chem. Phys. 126, 084901 (2007)), can be adapted to describe the thermal and mechanical denaturation…

Biological Physics · Physics 2011-08-30 Ana-Maria Florescu , Marc Joyeux

A lecture notes style review of the non-equilibrium statistical mechanics of recurrent neural networks with discrete and continuous neurons (e.g. Ising, graded-response, coupled-oscillators). To be published in the Handbook of Biological…

Disordered Systems and Neural Networks · Physics 2007-05-23 A. C. C. Coolen

The genus statistics is studied using large $N$-body simulations for several cosmological models. We consider the effects of nonlinear gravitational evolution, smoothing the particle data in fully nonlinear regime, and the redshift-space…

Astrophysics · Physics 2009-10-28 Takahiko Matsubara , Yasushi Suto

The mechanical model based on beads and springs, which we recently proposed to study non-specific DNA-protein interactions [J. Chem. Phys. 130, 015103 (2009)], was improved by describing proteins as sets of interconnected beads instead of…

Biological Physics · Physics 2009-10-29 Ana-Maria Florescu , Marc Joyeux

When it is viewed at the scale of a base pair, DNA appears as a nonlinear lattice. Modelling its properties is a fascinating goal. The detailed experiments that can be performed on this system impose constraints on the models and can be…

Statistical Mechanics · Physics 2009-08-26 Michel Peyrard , Santiago Cuesta-Lopez , Guillaume James

Information in the time distribution of points in a state space reconstructed from observed data yields a test for ``nonstationarity''. Framed in terms of a statistical hypothesis test, this numerical algorithm can discern whether some…

chao-dyn · Physics 2008-02-03 Matthew B. Kennel

Many physical systems can be mapped onto solved or "solvable" models of magnetism. In this work, we have mapped the statistical mechanics of columnar phases of ideally helical rigid DNA -- subject to the earlier found unusual, frustrated…

Biological Physics · Physics 2009-11-10 A. Wynveen , D. J. Lee , A. A. Kornyshev

We describe a statistical method to avoid biased estimation of the content of different particle species. We consider the case when the particle identification information strongly depends on some kinematical variables, whose distributions…

Data Analysis, Statistics and Probability · Physics 2011-06-16 Massimo Casarsa , Pierluigi Catastini , Giovanni Punzi , Luciano Ristori