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One of the key challenges to predict odor from molecular structure is unarguably our limited understanding of the odor space and the complexity of the underlying structure-odor relationships. Here, we show that the predictive performance of…

Quantitative Methods · Quantitative Biology 2025-08-14 Akshay Sajan , Stijn Sluis , Reza Haydarlou , Sanne Abeln , Pasquale Lisena , Raphael Troncy , Caro Verbeek , Inger Leemans , Halima Mouhib

We present a model for olfactory coding based on spatial representation of glomerular responses. In this model distinct odorants activate specific subsets of glomeruli, dependent upon the odorant's chemical identity and concentration. The…

Neurons and Cognition · Quantitative Biology 2007-05-23 A. Koulakov , A. Gelperin , D. Rinberg

The application of deep learning techniques on aroma-chemicals has resulted in models more accurate than human experts at predicting olfactory qualities. However, public research in this domain has been limited to predicting the qualities…

Machine Learning · Computer Science 2024-06-06 Laura Sisson , Aryan Amit Barsainyan , Mrityunjay Sharma , Ritesh Kumar

Given the structure of a novel molecule, there is still no one who can reliably predict what odor percept that molecule will evoke. The challenge comes from both the difficulty in quantitatively characterizing molecular structure, and the…

Neurons and Cognition · Quantitative Biology 2018-06-08 Daniel Kepple , Alexei Koulakov

Deep learning methods have been widely applied to visual and acoustic technology. In this paper, we proposed an odor labeling convolutional encoder-decoder (OLCE) for odor identification in machine olfaction. OLCE composes a convolutional…

Machine Learning · Computer Science 2021-01-07 Tengteng Wen , Zhuofeng Mo , Jingshan Li , Qi Liu , Liming Wu , Dehan Luo

Context: A substantial amount of work has been done to detect smells in source code using metrics-based and heuristics-based methods. Machine learning methods have been recently applied to detect source code smells; however, the current…

Software Engineering · Computer Science 2023-12-05 Tushar Sharma , Vasiliki Efstathiou , Panos Louridas , Diomidis Spinellis

It has been discovered before (arXiv:2306.07676) that for the selectivity gain due to fluctuations in the process of primary odor reception by olfactory receptor neuron (ORN) there exists an optimal concentration of odors at which increased…

Neurons and Cognition · Quantitative Biology 2025-04-15 A. K. Vidybida

In this paper, we propose a hypothesis regarding the travel and movement of chemicals between locations. We introduce six distinct methods to explain this process. The chemicals referred to in this article are those that we detect by the…

Molecular Networks · Quantitative Biology 2024-12-10 Usman Ahmad

In a 1950 article in Mind, decades before the existence of anything resembling an artificial intelligence system, Alan Turing addressed the question of how to test whether machines can think, or in modern terminology, whether a computer…

Other Computer Science · Computer Science 2016-11-11 David Harel

The human brain encodes stimuli from the environment into representations that form a sensory perception of the world. Despite recent advances in understanding visual and auditory perception, olfactory perception remains an under-explored…

Machine Learning · Computer Science 2024-11-06 Farzaneh Taleb , Miguel Vasco , Antônio H. Ribeiro , Mårten Björkman , Danica Kragic

In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We propose a novel strategy for encoding intensity-invariant stimuli identity that is based on…

Neurons and Cognition · Quantitative Biology 2016-09-09 Daniel Kepple , Hamza Giaffar , Dmitry Rinberg , Alexei Koulakov

Animals have evolved to rapidly detect and recognise brief and intermittent encounters with odour packages, exhibiting recognition capabilities within milliseconds. Artificial olfaction has faced challenges in achieving comparable results…

Animals use stereo sampling of odor concentration to localize sources and follow odor trails. We analyze the dynamics of a bilateral model that depends on the simultaneous comparison between odor concentrations detected by left and right…

Quantitative Methods · Quantitative Biology 2021-03-16 Nour Riman , Jonathan D. Victor , Sebastian D. Boie , Bard Ermentrout

In the field of food, as in other fields, the measurement of emotional responses to food and their sensory properties is a major challenge. In the present protocol, we propose a step-by-step procedure that allows a physiological description…

Neurons and Cognition · Quantitative Biology 2024-05-28 Maelle Moranges , Marc Plantevit , Moustafa Bensafi

Molecular communication (MC) has promising potential and a wide range of applications. However, odor-based communication which is common in nature, has not been sufficiently examined within the context of MC, yet. In this paper, we…

Emerging Technologies · Computer Science 2024-11-01 Fatih E. Bilgen , Ahmet B. Kilic , Ozgur B. Akan

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

In this work we consider the question of whether a simple diffusive model can explain the scent tracking behaviours found in nature. For this behaviour to occur, both the concentration of a scent and its gradient must be above some…

Soft Condensed Matter · Physics 2021-03-31 Gerard McCaul , Andreas Mershin , Denys I. Bondar

Mammalian odorant binding proteins (OBPs) have long been suggested to transport hydrophobic odorant molecules through the aqueous environment of the nasal mucus. While the function of OBPs as odorant transporters is supported by their…

Biomolecules · Quantitative Biology 2024-10-22 Massimiliano Paesani , Arthur G. Goetzee , Sanne Abeln , Halima Mouhib

Before aerosols can be sensed, sampling technologies must capture the particulate matter of interest. To that end, for systems deployed in open environments where the location of the aerosol is unknown, extending the reach of the sampler…

Systems and Control · Electrical Eng. & Systems 2025-05-26 Yahya Naveed , Julia Gersey , Pei Zhang

Odor visualization translates odor information and perception into visual outcomes and arouses the corresponding olfactory synesthesia, surpassing the spatial limitation that odors can only be perceived where they are present. Traditional…

Human-Computer Interaction · Computer Science 2026-02-05 Gang Yu , Yuchi Sun , Weining Yan , Xinyu Wang , Qi Lu