Related papers: A two phase harmonic model for left ventricular fu…
We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…
Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF…
A central problem in biomechanical studies of personalised human left ventricular (LV) modelling is estimating the material properties and biophysical parameters from in-vivo clinical measurements in a time frame suitable for use within a…
We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI)…
This work is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets, the free edges of which are supported by a system of chordae, which themselves are…
Introduction: Stenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart failure (HF). As myocardial energetics can be impaired during…
Medical therapy for patients with severe heart disease often relies on left ventricular assist devices (LVADs). It is an ongoing topic of research how complications like stagnation and thrombosis can be prevented by using artificial…
A parasystole from a heart-transplant patient is analysed using a beat-to-beat RR interval time series obtained from an electrocardiogram (ECG). The dysrhythmia, resulting from the co-existence of two pacemakers, the sinus node and an…
In a computational study we reveal a novel dynamical instability of excitation waves in the heartmuscle. The instability manifests itself as gradual local increase in the duration of the actionpotential which causes formation and…
We study the phase-synchronization properties of systolic and diastolic arterial pressure in healthy subjects. We find that delays in the oscillatory components of the time series depend on the frequency bands that are considered, in…
The clinical application of patient-specific modelling of the heart can provide valuable insights in supplementing and advancing methods of diagnosis as well as helping to devise the best possible therapeutic approach for each individual…
Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the…
The heart is the central part of the cardiovascular network. Its role is to pump blood to various body organs. Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications…
We consider the stochastic phase models for the community effect of cardiac muscle cells. The model is the extension of the stochastic integrate-and-fire model in which we incorporate the irreversibility after beating, induced beating and…
We present a reduced-order heart model with the aim of introducing a novel point of view in the interpretation of the pressure-volume loops. The novelty of the approach is based on the definition of active contraction as opposed to that of…
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy (CMP) that should be considered as a possible diagnosis because of its potential complications which are heart failure, ventricular arrhythmias, and embolic events. For…
The cardiologist's main tool for measuring systolic heart failure is left ventricular ejection fraction (LVEF). Trained cardiologist's report both a visual and machine-guided measurement of LVEF, but only use this machine-guided measurement…
A theoretical analysis of the mechanisms underlying the dynamics of gallbladder and heart pulsation could clarify the question regarding the classification as chaotic of the associated behaviour, eventually related to a normal and healthy…
This work presents a biventricular electromechanical human heart model that is comprehensive and clinically relevant, integrating a realistic 3D heart geometry with both systemic and pulmonary hemodynamics. The model uses a two-way…
Functional limitation after lung resection surgery has been consistently documented in clinical studies, and right ventricle (RV) dysfunction has been hypothesized as a contributing reason. However, the mechanisms of RV dysfunction after…