Cardiac Mechano-Electrical Dynamical Instability
Biological Physics
2019-08-15 v1 Medical Physics
Abstract
In a computational study we reveal a novel dynamical instability of excitation waves in the heartmuscle. The instability manifests itself as gradual local increase in the duration of the actionpotential which causes formation and hypermeandering of spiral waves. The mechanism is causedby stretch-activated currents that cause wave front-tail collisions and beat to beat elongation of theaction potential duration due to biexcitability. We discuss the importance of the instability for theonset and dynamics of cardiac arrhythmias.
Cite
@article{arxiv.1908.05144,
title = {Cardiac Mechano-Electrical Dynamical Instability},
author = {L. D. Weise and A. V. Panfilov},
journal= {arXiv preprint arXiv:1908.05144},
year = {2019}
}