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Biological systems are homochiral, raising the question of how a racemic mixture of prebiotically synthesized biomolecules could attain a homochiral state at the network level. Based on our recent results, we aim to address a related…

Biological Physics · Physics 2025-04-15 S. Furkan Ozturk , Dimitar D. Sasselov , John D. Sutherland

The role of asymmetry on the evolution of prebiotic homochirality is investigated in the context of autocatalytic polymerization reaction networks. A model featuring enantiometric cross-inhibition and chiral bias is used to study the…

Astrophysics · Physics 2009-11-11 Marcelo Gleiser

A cluster growth model is proposed to study chiral symmetry breaking in stirred crystallization from an achiral element. Achiral monomers are assumed to coagulate to form chiral clusters from dimers to hexamers. Due to the stirring, the…

Other Condensed Matter · Physics 2007-07-20 Yukio Saito , Hiroyuki Hyuga

Understanding the condensed-phase behavior of chiral molecules is important in biology, as well as in a range of technological applications, such as the manufacture of pharmaceuticals. Here, we use molecular dynamics simulations to study a…

Statistical Mechanics · Physics 2023-12-27 Pablo M. Piaggi , Roberto Car , Frank H. Stillinger , Pablo G. Debenedetti

Conceptualizing planetary habitability depends on understanding how living organisms originated and what features of environments are essential to foster abiogenesis. Estimates of the abundance of life's building blocks are confounded by…

Earth and Planetary Astrophysics · Physics 2018-07-12 Daniel S. Helman

The question of the onset of the homochirality on prebiotic Earth still remains a fundamental question in the quest for the origin of life. Recent works in this field introduce the concept of recycling, rather than the traditional open-flow…

Molecular Networks · Quantitative Biology 2011-05-23 Raphael Plasson

Living organisms exhibit consistent homochirality. It is argued that the specific, binary choice made is not an accident but is a consequence of parity violation in the weak interaction expressed by cosmic irradiation. The secondary muons…

Biological Physics · Physics 2019-11-07 Noemie Globus , Roger D. Blandford

A generalized autocatalytic model for chiral polymerization is investigated in detail. Apart from enantiomeric cross-inhibition, the model allows for the autogenic (non-catalytic) formation of left and right-handed monomers from a substrate…

Biomolecules · Quantitative Biology 2008-07-24 Marcelo Gleiser , Sara Imari Walker

Biomolecules that constitute life on Earth are chiral, but the precise mechanism by which homochirality emerged remains a mystery. In this work it is demonstrated that reactions of radical pairs, where one of the radical electron spins is…

Chemical Physics · Physics 2025-08-08 Thomas P Fay

To study the solution growth of crystals composed of chiral organic molecules, a spin-one Ising lattice gas model is proposed. The model turns out to be equivalent to the Blume-Emery-Griffiths model, which shows an equilibrium chiral…

Statistical Mechanics · Physics 2015-05-14 Yukio Saito , Hiroyuki Hyuga

The article seeks to formulate a synergetic law that is posited to be of common physicochemical and biological nature: an evolving system, possessing free energy and elements with chiral asymmetry may change the type of symmetry inside one…

Adaptation and Self-Organizing Systems · Physics 2012-12-10 Vsevolod A. Tverdislov

We show how spatiotemporal fluctuations can induce spontaneous symmetry breaking in systems which are perfectly symmetric in the absence of fluctuations. We illustrate this in the context of the autocatalytic production of chiral…

Soft Condensed Matter · Physics 2007-05-23 V. S. Gayathri , Madan Rao

Molecular chirality is critical to biochemical function, but it is unknown when chiral selectivity first became important in the evolutionary transition from geochemistry to biochemistry during the emergence of life. Here, we identify key…

Molecular Networks · Quantitative Biology 2025-05-05 John F. Malloy , Camerian Millsaps , Kamesh Narasimhan , Louie Slocombe , Cole Mathis , Leroy Cronin , Sara Imari Walker

We derive expressions for the scattering, extinction and conversion of the chirality of monochromatic light scattered by bodies which are characterized by a T-matrix. In analogy to the conditions obtained from the conservation of energy,…

Optics · Physics 2018-06-22 Philipp Gutsche , Manuel Nieto-Vesperinas

Reaction-diffusion systems where transition rates exhibit quenched disorder are common in physical and chemical systems. We study pair reactions on a periodic two-dimensional lattice, including continuous deposition and spontaneous…

Disordered Systems and Neural Networks · Physics 2010-11-10 A. Wolff , I. Lohmar , J. Krug , Y. Frank , O. Biham

Understanding chirality transfer from the molecular to the macroscopic scale poses a significant challenge in soft and biological condensed matter physics. Many nanorods of biological origin not only have chiral molecular features but also…

Soft Condensed Matter · Physics 2026-01-30 William S. Fall , Henricus H. Wensink

Heterogeneity in gene expression across isogenic cell populations can give rise to phenotypic diversity, even when cells are in homogenous environments. This diversity arises from the discrete, stochastic nature of biochemical reactions,…

Quantitative Methods · Quantitative Biology 2017-08-31 Zachary Fox , Brian Munsky

The paper treats a reaction-diffusion equation with hysteretic nonlinearity on a one-dimensional lattice. It arises as a result of the spatial discretization of the corresponding continuous model with so-called nontransverse initial data…

Analysis of PDEs · Mathematics 2016-01-22 Pavel Gurevich , Sergey Tikhomirov

The macroscopic behavior of the solution of a coupled system of partial differential equations arising in the modeling of reaction-diffusion processes in periodic porous media is analyzed. Our mathematical model can be used for studying…

Analysis of PDEs · Mathematics 2019-06-19 G. Cardone , C. Perugia , C. Timofte

Most animal body plans have some degree of left-right asymmetry. This chirality at the tissue and organ level is often assumed to originate from the intrinsic handedness of biological molecules. How this handedness might be transferred from…

Tissues and Organs · Quantitative Biology 2017-08-30 Jeremy Hadidjojo , David K. Lubensky