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This paper studies the application of the blended dynamics approach towards distributed optimization problem where the global cost function is given by a sum of local cost functions. The benefits include (i) individual cost function need…
An efficient computational approach for imaging binary-type physical properties suitable for various models in biomedical applications is developed and validated. The proposed methodology includes gradient-based multiscale optimization with…
Planning for legged-wheeled machines is typically done using trajectory optimization because of many degrees of freedom, thus rendering legged-wheeled planners prone to falling prey to bad local minima. We present a combined sampling and…
The US FDA's Project Optimus initiative that emphasizes dose optimization prior to marketing approval represents a pivotal shift in oncology drug development. It has a ripple effect for rethinking what changes may be made to conventional…
Introduction: Increasing interest in real-world evidence has fueled the development of study designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three designs to evaluate the difference in risk of major adverse…
The rapidly evolving field of engineering design of functional surfaces necessitates sophisticated tools to manage the inherent complexity of high-dimensional design spaces. This survey paper offers a scoping review, i.e., a literature…
Isogeometric analysis (IGA) has emerged as a promising approach in the field of structural optimization, benefiting from the seamless integration between the computer-aided design (CAD) geometry and the analysis model by employing…
A systematic approach for high-speed via transition design is proposed. The effects of via barrel radius, anti-pad size, and the distance from adjacent stitching (GND) vias on bandwidth are analyzed and characterized. Guidelines for…
Traditional stereo matching algorithms like Semi-Global Block Matching (SGBM) with Weighted Least Squares (WLS) filtering offer speed advantages over neural networks for UAV applications, generating disparity maps in approximately 0.5…
Particle-based shape modeling (PSM) is a popular approach to automatically quantify shape variability in populations of anatomies. The PSM family of methods employs optimization to automatically populate a dense set of corresponding…
We describe and analyze algorithms for shape-constrained symbolic regression, which allows the inclusion of prior knowledge about the shape of the regression function. This is relevant in many areas of engineering -- in particular whenever…
Fitness landscape analysis investigates features with a high influence on the performance of optimization algorithms, aiming to take advantage of the addressed problem characteristics. In this work, a fitness landscape analysis using…
Purpose: A promising approach to enable FLASH conformal proton therapy is to passively degrade a single energy layer using a patient-specific range modulator. We propose an innovative method to directly optimize the geometrical…
In this work, to efficiently help escape the stationary and saddle points, we propose, analyze, and generalize a stochastic strategy performed as an operator for a first-order gradient descent algorithm in order to increase the target…
Methods: A phase space file in a plane at 202 mm downstream of the beam exit window is generated through tuning parameters to match FDC results with measured or MCNPX Monte Carlo-simulated integrated depth-dose distribution (IDD) and…
Multi-material structural topology and shape optimization problems are formulated within a phase field approach. First-order conditions are stated and the relation of the necessary conditions to classical shape derivatives are discussed. An…
In this article, we present a general mode-conversion algorithm allowing to build an optical system composed of an alternation of phase masks and free propagations. The originality of our approach lies in the introduction of free parameters…
We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…
This research delves into optimizing mechanism design, with an emphasis on the energy efficiency and the expansive design possibilities of reciprocating mechanisms. It investigates how to efficiently integrate Computer-Aided Design (CAD)…
In this paper, we propose an algorithm for the formation of multiple UAVs used in vision-based inspection of infrastructure. A path planning algorithm is first developed by using a variant of the particle swarm optimisation, named…