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Evidence from skeletal remains and pictorial records for the past several millennia established that humans have had a very inadequate ascorbic acid intake and commonly exhibited signs of frank scurvy, as well as the invisible signs of…

Physics and Society · Physics 2007-05-23 John T. A. Ely

Many see modern science as having serious defects, intellectual, social, moral. Few see this as having anything to do with the philosophy of science. I argue that many diverse ills of modern science are a consequence of the fact that the…

History and Philosophy of Physics · Physics 2011-03-11 Nicholas Maxwell

We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept of Misrepair and the concept of accumulation of Misrepairs.…

Tissues and Organs · Quantitative Biology 2017-01-04 Jicun Wang-Michelitsch , Thomas Michelitsch

The discipline of `theoretical biology' has been developing from its inception several decades ago almost in parallel with the advances in biology, so much so that the latter is often considered to be almost exclusively an empirical…

Biological Physics · Physics 2025-06-10 Shakti N. Menon , Sitabhra Sinha

Nuclear fission represents the ultimate test for microscopic theories of nuclear structure and reactions. Fission is a large-amplitude, time-dependent phenomenon taking place in a self-bound, strongly-interacting many-body system. It…

Nuclear Theory · Physics 2025-10-29 Nicolas Schunck

For four decades it has been argued that we need to adopt a new conception of science called aim-oriented empiricism. This has far-reaching implications and repercussions for science, the philosophy of science, academic inquiry in general,…

History and Philosophy of Physics · Physics 2015-09-03 Nicholas Maxwell

It is now increasingly realized that the underlying mechanism which governs aging (ageing) is a complex interplay of genetic regulation and damage-accumulation. "Aging as a result of accumulation of 'faults' on cellular and molecular…

Tissues and Organs · Quantitative Biology 2011-03-31 Jicun Wang , Thomas Michelitsch , Arne Wunderlin , Ravi Mahadeva

The reader surely knows what particles physics is about: finding building blocks of nature that appear elementary at a given time and study their interactions - so why in the world this essay? The problem is how to arrive at a fundamental…

High Energy Physics - Phenomenology · Physics 2025-04-21 Goran Senjanović

Some attack scientific rationality, others defend it, but both miss the point. What both parties take to be scientific rationality is actually a species of irrationality masquerading as scientific rationality. The current orthodox…

History and Philosophy of Physics · Physics 2020-01-29 Nicholas Maxwell

Have you ever wondered why we have never heard of psychics and palm readers winning millions of dollars in state or local lotteries or becoming Wall Street wolfs? Neither have I. Yet we are constantly bombarded by tabloid news on how…

Popular Physics · Physics 2019-06-17 Maxim Sukharev

Linear waste management systems are unsustainable and contribute to environmental degradation, economic inequity, and health disparities. Among the array of environmental challenges stemming from anthropogenic impacts, the management of…

Quantitative Methods · Quantitative Biology 2024-09-12 Jeff Meilander , J. Gregory Caporaso

Despite the extraordinary successes the two great bastions of $20^{th}$ century science (Quantum Theory and General Relativity) are troubled with serious conceptual and mathematical difficulties. As a result, further growth of fundamental…

Popular Physics · Physics 2007-05-23 Bhag C. Chauhan

Quantum theory has been proved as an outstanding mystery in modern science. The predictions of science have turned out to be probabilistic. The principle of determinism has failed. For systems like weather, earthquakes, rolling dices etc...…

Popular Physics · Physics 2007-05-23 Bhag C. Chauhan

The question of why we age is a fundamental one. It is about who we are, and it also might have critical practical aspects as we try to find ways to age slower. Or to not age at all. Different reasons point at distinct strategies for the…

Populations and Evolution · Quantitative Biology 2020-11-10 André C. R. Martins

As AI systems are increasingly used to guide decisions, it is essential that they follow ethical principles. A core principle in medicine is non-maleficence, often equated with ``do no harm''. A formal definition of harm based on…

Applications · Statistics 2025-12-30 Amit N. Sawant , Mats J. Stensrud

Many theories have been proposed to answer two questions on aging: "Why do we age?" and "How do we age?" Among them, evolutionary theories are proposed to interpret the evolutionary advantage of aging, and "saving resources for group…

Other Quantitative Biology · Quantitative Biology 2017-01-04 Jicun Wang-Michelitsch , Thomas Michelitsch

There is overwhelming evidence that the continued and widespread use of untested spreadsheets in business gives rise to regular, significant and unexpected financial losses. Whilst this is worrying, it is perhaps a relatively minor concern…

Computers and Society · Computer Science 2024-12-31 Grenville J. Croll , Raymond J. Butler

Human understanding of randomness and variation is shaped by a number of cognitive biases. Here we relate a lesser-known cognitive bias, the "outcome orientation", to medical questions and describe the harm that the outcome orientation can…

Physics Education · Physics 2017-02-20 Parris Taylor Humphrey , Joanna Masel

Would another origin of life resemble Earth's biochemical use of amino acids? Here we review current knowledge at three levels: 1) Could other classes of chemical structure serve as building blocks for biopolymer structure and catalysis?…

Biomolecules · Quantitative Biology 2024-06-04 Sean M. Brown , Christopher Mayer-Bacon , Stephen Freeland

An attempt to redefine science in the 21st century (BK Jennings, On the Nature of Science, Physics in Canada, 63(7) 2007) has abandoned traditional notions of natural law and objective reality, blurred the distinctions between natural…

History and Philosophy of Physics · Physics 2008-12-31 Amy Courtney , Michael Courtney
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