Related papers: Two adaptation processes in auditory hair cells to…
Cortical neurons exhibit a hierarchy of timescales across brain regions in response to input stimuli, which is thought to be crucial for information processing of different temporal scales. Modeling studies suggest that both intra-regional…
This work reviews the human auditory system, elucidating some of the specialized mechanisms and non-linear pathways along the chain of events between physical sound and its perception. Customary relationships between frequency, time, and…
On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for investigating finite variations of variables from…
Motile cilia are slender, hair-like cellular appendages that spontaneously oscillate under the action of internal molecular motors and are typically found in dense arrays. These active filaments coordinate their beating to generate…
The auditory system displays remarkable sensitivity and frequency discrimination, attributes shown to rely on an amplification process that involves a mechanical as well as a biochemical response. Models that display proximity to an…
The cochlea or inner ear has a remarkable ability to amplify sound signals. This is understood to derive at least in part from some active process that magnifies vibrations of the basilar membrane (BM) and the cochlear partition in which it…
Past work has reported inverted-U relationships between arousal and auditory task performance, but the underlying neural network mechanisms remain unclear. To make progress, we recorded auditory cortex activity from behaving mice during…
In addition to thermal noise, which is essential to promote conformational transitions in biopolymers, cellular environment is replete with a spectrum of athermal fluctuations that are produced from a plethora of active processes. To…
Neurons have the capability of transforming information from a digital signal at the dendrites of the presynaptic termi- nal to an analogous wave at the synaptic cleft and back to a digital pulse when they achieve the required voltage for…
Mechanical oscillations are important for many cellular processes, e.g. the beating of cilia and flagella or the sensation of sound by hair cells. These dynamic states originate from spontaneous oscillations of molecular motors. A…
The feedback between mechanical and chemical signals plays a key role in controlling many biological processes and collective cell behavior. Here we focus on the emergence of spatiotemporal density waves in a one-dimensional "cell train."…
A sound stimulus entering the inner ear excites a deformation of the basilar membrane which travels along the cochlea towards the apex. It is well established that this wave-like disturbance is amplified by an active system. Recently, it…
Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…
The effectiveness of outer hair cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian hearing, depends on the mechanical power output of these cells. Electromechanical coupling…
Biophysical models describing complex, cellular phenomena typically include systems of nonlinear differential equations with many free parameters. While experimental measurements can fix some parameters, those describing internal cellular…
We study the interplay between active Brownian particles (ABPs) and a hairy surface in two dimensional geometry. We find that the increase of propelling force leads to and enhances inhomogeneous accumulation of ABPs inside the brush region.…
An active dissipative process organizes auditory frequency analysis in the mammalian cochlea. A minimal active beam model reveals that a spatially varying viscous coupling operator, $\partial_{xx}\kappa\partial_{xx}$, generates dissipative…
High auditory sensitivity, sharp frequency selectivity, and otoacoustic emissions are signatures of active amplification of the cochlea. The human ear can also detect very large amplitude sound without being damaged as long as the exposed…
Cilia and flagella are hair-like extensions of eukaryotic cells which generate oscillatory beat patterns that can propel micro-organisms and create fluid flows near cellular surfaces. The evolutionary highly conserved core of cilia and…
Building mathematical models of brains is difficult because of the sheer complexity of the problem. One potential starting point is through basal cognition, which gives abstract representation of a range of organisms without central nervous…