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We prove that for Gaussian random normal matrices the correlation function has universal behavior. Using the technique of orthogonal polynomials and identities similar to the Christoffel-Darboux formula, we find that in the limit, as the…

Mathematical Physics · Physics 2013-12-03 Roman Riser

Changes in the extent of local concavity along with changes in surface roughness of binding sites of proteins have long been considered as useful markers to identify functional sites of proteins. However, an algorithm that describes the…

Biomolecules · Quantitative Biology 2011-11-29 Anirban Banerji

Simple coarse-grained models, such as the Gaussian Network Model, have been shown to capture some of the features of equilibrium protein dynamics. We extend this model by using atomic contacts to define residue interactions and introducing…

Biomolecules · Quantitative Biology 2009-11-13 Dmitry A. Kondrashov , Qiang Cui , George N. Phillips

The past decade has witnessed the development and success of coarse-grained network models of proteins for predicting many equilibrium properties related to collective modes of motion. Curiously, the results are usually robust towards the…

Molecular Networks · Quantitative Biology 2008-09-23 Canan Atilgan , Ibrahim Inanc , Ali Rana Atilgan

Protein conformational fluctuations are highly complex and exhibit long-term correlations. Here, molecular dynamics simulations of small proteins demonstrate that these conformational fluctuations directly affect the protein's instantaneous…

Statistical Mechanics · Physics 2021-03-31 Eiji Yamamoto , Takuma Akimoto , Ayori Mitsutake , Ralf Metzler

Recent experiments using fluorescence spectroscopy have been able to probe the dynamics of conformational fluctuations in proteins. The fluctuations are Gaussian but do not decay exponentially, and are therefore, non-Markovian. We present a…

Statistical Mechanics · Physics 2008-10-14 Arti Dua , R. Adhikari

We introduce a deductive statistical mechanics approach for granular materials which is formally built from few realistic physical assumptions. The main finding is an universal behavior for the distribution of the density fluctuations. Such…

Soft Condensed Matter · Physics 2008-06-25 T. Aste , T. Di Matteo

Random-matrix theory is used to study the mesoscopic fluctuations of the excitation gap in a metal grain or quantum dot induced by the proximity to a superconductor. We propose that the probability distribution of the gap is a universal…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 M. G. Vavilov , P. W. Brouwer , V. Ambegaokar , C. W. J. Beenakker

We show that spectral fluctuation of interaction matrices of yeast a core protein interaction network and a metabolic network follows the description of the Gaussian orthogonal ensemble (GOE) of random matrix theory (RMT). Furthermore, we…

Molecular Networks · Quantitative Biology 2009-11-11 Feng Luo , Jianxin Zhong , Yunfeng Yang , Richard H. Scheuermann , Jizhong Zhou

Protein domains are found on genomes with notable statistical distributions, which bear a high degree of similarity. Previous work has shown how these distributions can be accounted for by simple models, where the main ingredients are…

Genomics · Quantitative Biology 2008-07-14 M. Cosentino Lagomarsino , A. L. Sellerio , P. D. Heijning , B. Bassetti

The biological activity and functional specificity of proteins depend on their native three-dimensional structures determined by inter- and intra-molecular interactions. In this paper, we investigate the geometrical factor of protein…

Biological Physics · Physics 2012-03-02 Ming-Chya Wu , Mai Suan Li , Wen-Jong Ma , Maksim Kouza , Chin-Kun Hu

We study the universal nature of global fluctuations in the critical regime of the spherical model by evaluating the exact distribution of the magnetization and its absolute value in the thermodynamical limit, in the presence of a conjugate…

Statistical Mechanics · Physics 2015-06-11 Jean-Yves Fortin , Sophie Mantelli

Understanding the link between structure and function in proteins is fundamental in molecular biology and proteomics. A central question in this context is whether allostery - where the binding of a molecule at one site affects the activity…

Statistical Mechanics · Physics 2025-06-02 Giulio Costantini , Lorenzo Caprini , Umberto Marini Bettolo Marconi , Fabio Cecconi

The probability density function of single-point velocity fluctuations in turbulence is studied systematically using Fourier coefficients in the energy-containing range. In ideal turbulence where energy-containing motions are random and…

Fluid Dynamics · Physics 2009-11-10 H. Mouri , M. Takaoka , A. Hori , Y. Kawashima

We study a large data set of protein structure ensembles of very diverse sizes determined by nuclear magnetic resonance. By examining the distance-dependent correlations in the displacement of residues pairs and conducting finite size…

Biological Physics · Physics 2017-03-01 Qian-Yuan Tang , Yang-Yang Zhang , Jun Wang , Wei Wang , Dante R. Chialvo

We apply random matrix theory to complex networks. We show that nearest neighbor spacing distribution of the eigenvalues of the adjacency matrices of various model networks, namely scale-free, small-world and random networks follow…

Adaptation and Self-Organizing Systems · Physics 2016-09-08 Jayendra N. Bandyopadhyay , Sarika Jalan

We study the distribution of resistance fluctuations of conducting thin films with different levels of internal disorder. The film is modeled as a resistor network in a steady state determined by the competition between two biased…

Disordered Systems and Neural Networks · Physics 2009-11-10 C. Pennetta , E. Alfinito , L. Reggiani , S. Ruffo

Many fluctuating systems consist of macroscopic structures in addition to noisy signals. Thus, for this class of fluctuating systems, the scaling behaviors are very complicated. Such phenomena are quite commonly observed in Nature, ranging…

Statistical Mechanics · Physics 2007-05-23 Ning-Ning Pang , Hisen-Ching Kao , Wen-Jer Tzeng

A new model for stock price fluctuations is proposed, based upon an analogy with the motion of tracers in Gaussian random fields, as used in turbulent dispersion models and in studies of transport in dynamically disordered media. Analytical…

Statistical Mechanics · Physics 2009-11-10 James P. Gleeson

Covariance matrices of amino acid displacements, commonly used to characterize the large-scale movements of proteins, are investigated through the prism of Random Matrix Theory. Bulk universality is detected in the local spacing statistics…

Quantitative Methods · Quantitative Biology 2013-05-29 Raffaello Potestio , Fabio Caccioli , Pierpaolo Vivo