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The study of chemical reactions in environments under nonequilibrium conditions has been of interest recently in a variety of contexts, including current-induced reactions in molecular junctions and scanning tunneling microscopy…

Chemical Physics · Physics 2022-07-27 Yaling Ke , Christoph Kaspar , André Erpenbeck , Uri Peskin , Michael Thoss

Here we focus on the challenge of verifying the correctness of molecular implementations of abstract chemical reaction networks, where operation in a well-mixed "soup" of molecules is stochastic, asynchronous, concurrent, and often involves…

Computational Engineering, Finance, and Science · Computer Science 2019-10-01 Seung Woo Shin , Chris Thachuk , Erik Winfree

We consider the problem of estimating the mean entropy production rate in a nonequilibrium process from the measurements of first-passage quantities associated with a single current. For first-passage processes with large thresholds, Refs.…

Statistical Mechanics · Physics 2025-06-05 Izaak Neri

Calculating how long a coupled multi-species reactive-diffusive transport process in a heterogeneous medium takes to effectively reach steady state is important in many applications. In this paper, we show how the time required for such…

Biological Physics · Physics 2020-07-22 Elliot J. Carr , Jonah J. Klowss

The most general exclusion single species reaction-diffusion models with nearest-neighbor interactions one a one dimensional lattice are investigated, for which the evolution of full intervals are closed. Using a generating function method,…

Statistical Mechanics · Physics 2012-08-09 Amir Aghamohammadi , Mohammad Khorrami

Networks and network computations have become a primary mathematical tool for analyzing the structure of many kinds of complex systems, ranging from the Internet and transportation networks to biochemical interactions and social networks. A…

Social and Information Networks · Computer Science 2023-07-11 M. E. J. Newman

In this paper we address the problem of the calculation of the mean first passage time (MFPT) on generic graphs. We focus in particular on the mean first passage time on a node 's' for a random walker starting from a generic, unknown, node…

Statistical Mechanics · Physics 2007-05-23 Andrea Baronchelli , Vittorio Loreto

Reactions forming a pathway can be rewritten by making explicit the different molecular components involved in them. A molecular component represents a biological entity (e.g. a protein) in all its states (free, bound, degraded, etc.). In…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Andrea Maggiolo-Schettini , Paolo Milazzo , Giovanni Pardini

Decomposition of biomolecular reaction networks into pathways is a powerful approach to the analysis of metabolic and signalling networks. Current approaches based on analysis of the stoichiometric matrix reveal information about…

Molecular Networks · Quantitative Biology 2018-08-14 Peter J. Gawthrop , Edmund J. Crampin

Quantifying animal interactions is crucial for understanding various ecological processes, including social community structures, predator-prey dynamics, spreading of pathogens and information. Despite the ubiquity of interaction processes…

Statistical Mechanics · Physics 2023-10-06 Debraj Das , V. M. Kenkre , Ran Nathan , Luca Giuggioli

The first-passage time is proposed as an independent thermodynamic parameter of the statistical distribution that generalizes the Gibbs distribution. The theory does not include the determination of the first passage statistics itself. A…

Statistical Mechanics · Physics 2022-08-22 V. V. Ryazanov

First passage phenomena arise across physics, biology, and finance when stochastic processes first reach a threshold, triggering downstream events. Examples include the irreversible exit from a domain, a biochemical reaction, a financial…

Statistical Mechanics · Physics 2026-04-06 Maria R. D'Orsogna , Alan E. Lindsay , Thomas Hillen

We develop a data-driven method to learn chemical reaction networks from trajectory data. Modeling the reaction system as a continuous-time Markov chain and assuming the system is fully observed, our method learns the propensity functions…

Optimization and Control · Mathematics 2019-11-25 Wei Zhang , Stefan Klus , Tim Conrad , Christof Schütte

We introduce a perturbative method to calculate all moments of the first-passage time distribution in stochastic one-dimensional processes which are subject to both white and coloured noise. This class of non-Markovian processes is at the…

Statistical Mechanics · Physics 2021-02-12 Benjamin Walter , Gunnar Pruessner , Guillaume Salbreux

The free energy profile of a reaction can be estimated in a molecular-dynamics approach by imposing a mechanical constraint along a reaction coordinate (RC). Many recent studies have shown that the temperature can greatly influence the path…

Chemical Physics · Physics 2009-11-11 P. Fleurat-Lessard , T. Ziegler

Radio propagation modeling is essential in telecommunication research, as radio channels result from complex interactions with environmental objects. Recently, Machine Learning has been attracting attention as a potential alternative to…

Chemical kinetic mechanisms can be represented by sets of elementary reactions that are easily translated into mathematical terms using physicochemical relationships. The schematic representation of reactions captures the interactions…

Optimization and Control · Mathematics 2019-02-12 Farshad Harirchi , Doohyun Kim , Omar A. Khalil , Sijia Liu , Paolo Elvati , Angela Violi , Alfred O. Hero

Stochastic reaction network models arise in intracellular chemical reactions, epidemiological models and other population process models, and are a class of continuous time Markov chains which have the nonnegative integer lattice as state…

Numerical Analysis · Mathematics 2024-07-26 Muruhan Rathinam , Mingkai Yu

We study measures of the amount of time required for transient flow in heterogeneous porous media to effectively reach steady state, also known as the response time. Here, we develop a new approach that extends the concept of mean action…

Fluid Dynamics · Physics 2018-02-12 Elliot J. Carr , Matthew J. Simpson

We propose a novel measure valued process which models the behaviour of chemical reaction networks in spatially heterogeneous systems. It models reaction dynamics between different molecular species and continuous movement of molecules in…

Probability · Mathematics 2022-01-12 Lea Popovic , Amandine Veber