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Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

Model Predictive Path Integral (MPPI) control is a type of sampling-based model predictive control that simulates thousands of trajectories and uses these trajectories to synthesize optimal controls on-the-fly. In practice, however, MPPI…

Robotics · Computer Science 2023-02-24 Ji Yin , Charles Dawson , Chuchu Fan , Panagiotis Tsiotras

To provide the generic clock, trigger and control function and fulfill the data transmission performance requirement in high energy physics (HEP) experiments, a MicroTCA Fast Control board (uFC) was developed based on the Advanced Mezzanine…

Instrumentation and Detectors · Physics 2019-09-04 Jie Zhang , Hangxu Li , Jingzi Gu , Xiaoshan Jiang

The intense neutron source for development of fusion materials planned by international collaboration makes a new step to clarify the technical issues for realizing the 40 MeV, 250 mA deuteron beam facility. The baseline concept employs two…

Accelerator Physics · Physics 2007-05-23 M. Sugimoto , M. Kinsho , H. Takeuchi

In this work, we propose an extension of the previously introduced Corridor Model Predictive Control scheme for high-order and distributed systems, with an application for on-orbit inspection. To this end, we leverage high order control…

Systems and Control · Electrical Eng. & Systems 2024-09-21 Gregorio Marchesini , Pedro Roque , Dimos V. Dimarogonas

In this work, we report on the advantageous aspects of the i-TED Compton imager for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that…

Managing energy and thermal profiles is critical for many-core HPC processors with hundreds of application-class processing elements (PEs). Advanced model predictive control (MPC) delivers state-of-the-art performance but requires solving…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-13 Alessandro Ottaviano , Andrino Meli , Paul Scheffler , Giovanni Bambini , Robert Balas , Davide Rossi , Andrea Bartolini , Luca Benini

We are developing a high-current cyclotron as a driver for the IsoDAR neutrino experiment. It accelerates 5 mA H2+ to 60 MeV/amu, after which the electron is removed to produce a 10 mA, 60 MeV proton beam. The enabling innovations that…

Accelerator Physics · Physics 2024-04-30 D. Winklehner , J. R. Alonso , J. M. Conrad

Multimodal prehabilitation for colorectal cancer (CRC) surgery aims to optimize patient fitness and reduce postoperative complications. While telemonitoring's clinical value in supporting decision-making is recognized, patient perspectives…

Human-Computer Interaction · Computer Science 2025-09-17 Irina Bianca Serban , Dimitra Dritsa , David ten Cate , Loes Janssen , Margot Heijmans , Sara Colombo , Aarnout Brombacher , Steven Houben

The PROMETHEUS Project is ongoing for the design and development of a 4-vane radio frequency quadrupole (RFQ) together with its H+ ion source, a low energy beam transport (LEBT) line and diagnostics section. The main goal of the project is…

The radiotherapy of malignant diseases has reached much progress during the past decade. Thus, intensity modulated radiation therapy (IMRT) and VMAT (Rapidarc) now belong to the standard modalities of tumor treatment with high energy…

Medical Physics · Physics 2016-11-15 W. Ulmer , A. Carabe-Fernandez

Tumor burden assessment by magnetic resonance imaging (MRI) is central to the evaluation of treatment response for glioblastoma. This assessment is complex to perform and associated with high variability due to the high heterogeneity and…

The IOTA Proton Injector (IPI), currently under installation at the Fermilab Accelerator Science and Technology facility, is a beamline capable of delivering 20-mA pulses of protons at 2.5 MeV to the Integrable Optics Test Accelerator…

Accelerator Physics · Physics 2023-05-18 D. Edstrom , D. Broemmelsiek , K. Carlson , J. -P. Carneiro , H. Piekarz , A. Romanov , A. Shemyakin , A. Valishev

The LHCb experiment(Fig. 1), that is presently taking data at CERN (European Center for Nuclear Research) Large Hadron Collider (LHC), aims at the study of CP violation in the B meson sector. Its key elements is the Muon detector [1], which…

Instrumentation and Detectors · Physics 2015-12-09 Valerio Bocci

Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In…

Accelerator Physics · Physics 2014-11-21 A. Garonna , U. Amaldi , R. Bonomi , D. Campo , A. Degiovanni , M. Garlasché , I. Mondino , V. Rizzoglio , S. Verdú Andrés

Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…

In the context of the general consolidation of the CERN ISOLDE facility, a project has been started to upgrade the ISOLDE control system. We describe the new ISOLDE control system, emphasizing the systematic use of industrial components…

Accelerator Physics · Physics 2007-05-23 J. Allard , O. Jonsson , F. Locci , G. Mornacchi

The high-intensity proton beam of the TRIUMF 500 MeV cyclotron offers unique opportunities to produce rare isotopes by irradiating a variety of targets. In particular, the ISAC (Isotope Separation and ACceleration) facility provides the…

Accelerator Physics · Physics 2023-06-14 Peter Kunz , Jens Lassen , Corina Andreoiu , Fatima H. Garcia , Hua Yang , Valery Radchenko

Designed to provide quality assurance for ion-beam radiotherapy, the prototype fIVI (filtered Interaction Vertex Imaging) Range Monitoring System is a two-layer tracker which employs double-sided strip-segmented silicon detectors. To meet…

Instrumentation and Detectors · Physics 2025-12-19 Devin Hymers , Sebastian Schroeder , Olga Bertini , Johann Heuser , Joerg Lehnert , Christian Joachim Schmidt , Dennis Mücher

When using superconducting (SC) magnets in a gantry for proton therapy, the gantry will benefit from some reduction in size and a large reduction in weight. In this contribution we show an important additional advantage of SC magnets in…

Medical Physics · Physics 2020-01-10 K. P. Nesteruk , C. Calzolaio , D. Meer , V. Rizzoglio , M. Seidel , J. M. Schippers