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Related papers: Molecular Theory of Hydrophobic Effects: ``She is …

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A theoretical approach is developed to quantify hydrophobic hydration and interactions on a molecular scale, with the goal of gaining insight into the molecular origins of hydrophobic effects. The model is based on the fundamental relation…

Chemical Physics · Physics 2016-08-15 G. Hummer , S. Garde , A. E. García , M. E. Paulaitis , L. R. Pratt

This review focuses on the striking recent progress in solving for hydrophobic interactions between small inert molecules. We discuss several new understandings. Firstly, the _inverse _temperature phenomenology of hydrophobic interactions,…

Chemical Physics · Physics 2016-04-27 L. R. Pratt , Mangesh I. Chaudhari , Susan B. Rempe

A comprehensive, semi-quantitative model for the thermodynamics of hydrophobic solvation is presented. The model is based on a very simple premise suggested by the scaled particle theory and treats both solute and solvent molecules as hard…

Biological Physics · Physics 2007-05-23 Hong Qian

Water offers a large temperature domain of stable liquid, and the characteristic hydrophobic effects are first a consequence of the temperature insensitivity of equation-of-state features of the aqueous medium, compared to other liquids. On…

Biological Physics · Physics 2007-05-23 Lawrence R. Pratt , Andrew Pohorille , D. Asthagiri

The aversion of hydrophobic solutes for water drives diverse interactions and assemblies across materials science, biology and beyond. % Here, we review the theoretical, computational and experimental developments which underpin a…

Soft Condensed Matter · Physics 2022-10-05 Nicholas B. Rego , Amish J. Patel

A theoretical model for the effect of water hydrogen bonding on the thermodynamics of hydrophobic hydration is proposed as a combination of the classical density functional theory with the recently developed probabilistic approach to water…

Statistical Mechanics · Physics 2011-06-16 Yuri S. Djikaev

The hydrophobic effect stabilizes the native structure of proteins by minimizing the unfavourable interactions between hydrophobic residues and water through the formation of a hydrophobic core. Here we include the entropic and enthalpic…

Soft Condensed Matter · Physics 2016-03-23 Erik van Dijk , Patrick Varilly , Tuomas Knowles , Daan Frenkel , Sanne Abeln

We present an extension of our recently introduced molecular density functional theory of water [G. Jeanmairet et al., J. Phys. Chem. Lett. 4, 619, 2013] to the solvation of hydrophobic solutes of various sizes, going from angstroms to…

Chemical Physics · Physics 2013-10-21 Guillaume Jeanmairet , Maximilien Levesque , Daniel Borgis

Hydrophobic interactions provide driving forces for protein folding, membrane formation, and oil-water separation. Motivated by information theory, the poorly understood nonpolar solute interactions in water are investigated. A simple…

chem-ph · Physics 2008-02-03 G. Hummer , S. Garde , A. E. Garcia , A. Pohorille , L. R. Pratt

We discuss the simple microscopic derivation of a hydrophobic effect. Our approach is based on the standard functional representation of the partition function of interacting classical particles and subsequent passage to collective…

Statistical Mechanics · Physics 2016-08-31 G. Sitnikov , S. Nechaev

Water near hydrophobic surfaces is like that at a liquid-vapor interface, where fluctuations in water density are substantially enhanced compared to that in bulk water. Here we use molecular simulations with specialized sampling techniques…

Recent progress on molecular theories of hydration of nonpolar solutes in aqueous solution has led to new ways of thinking about the old issue of free, or "available," volume in liquids. This article surveys the principal new results with…

Chemical Physics · Physics 2007-05-23 Lawrence R. Pratt , Shekhar Garde , Gerhard Hummer

The hydrophobic effect is the dominant force which drives a protein towards its native state, but its physics has not been thoroughly understood yet. We introduce an exactly solvable model of the solvation of non-polar molecules in water,…

Statistical Mechanics · Physics 2007-05-23 Pierpaolo Bruscolini , Lapo Casetti

Among the various features of amino acids, the hydrophobic property has most visible impact on stability of a sequence folding. This is mentioned in many protein folding related work, in this paper we more elaborately discuss the…

Computational Engineering, Finance, and Science · Computer Science 2013-12-16 Geetika Silakari Pandey , R. C. Jain

The tendency of amphiphilic molecules to form micelles in aqueous solution is a consequence of the hydrophobic effect. The fundamental difference between micelle assembly and macroscopic phase separation is the stoichiometric constraint…

Soft Condensed Matter · Physics 2007-05-23 Lutz Maibaum , Aaron R. Dinner , David Chandler

The solvation of hydrophobic solutes in water is special because liquid and gas are almost at coexistence. In the common hypernetted chain approximation to integral equations, or equivalently in the homogenous reference fluid of molecular…

Chemical Physics · Physics 2015-04-21 Guillaume Jeanmairet , Maximilien Levesque , Volodymyr Sergiievskyi , Daniel Borgis

Interfaces are a most common motif in complex systems. To understand how the presence of interfaces affect hydrophobic phenomena, we use molecular simulations and theory to study hydration of solutes at interfaces. The solutes range in size…

Soft Condensed Matter · Physics 2014-09-05 Amish J. Patel , Patrick Varilly , Sumanth N. Jamadagni , Hari Acharya , Shekhar Garde , David Chandler

Colloidal aggregation could be implemented in various fields ranging from purely colloidal thermodynamics to protein interactions, their stability, and maybe folding. Indeed, colloidal aggregation is closely linked to the so-called…

Soft Condensed Matter · Physics 2013-01-03 Pierre de Thier

The role of solute attractive forces on hydrophobic interactions is studied by coordinated development of theory and simulation results for Ar atoms in water. We present a concise derivation of the local molecular field (LMF) theory for the…

Chemical Physics · Physics 2015-10-28 M. I. Chaudhari , S. B. Rempe , D. Asthagiri , L. Tan , L. R. Pratt

The behavior of proteins near interfaces is relevant for biological and medical purposes. Previous results in bulk show that, when the protein concentration increases, the proteins unfold and, at higher concentrations, aggregate. Here, we…

Soft Condensed Matter · Physics 2021-01-19 David March , Valentino Bianco , Giancarlo Franzese
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