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We consider a minimalistic dynamic model of the idiotypic network of B-lymphocytes. A network node represents a population of B-lymphocytes of the same specificity (idiotype), which is encoded by a bitstring. The links of the network…

Cell Behavior · Quantitative Biology 2015-06-03 Holger Schmidtchen , Mario Thüne , Ulrich Behn

We consider self-tolerance and its failure -autoimmunity- in a minimal mathematical model of the idiotypic network. A node in the network represents a clone of B-lymphocytes and its antibodies of the same idiotype which is encoded by a…

Cell Behavior · Quantitative Biology 2016-09-20 Stefan Landmann , Nicolas Preuss , Ulrich Behn

We introduce a class of weighted graphs whose properties are meant to mimic the topological features of idiotypic networks, namely the interaction networks involving the B-core of the immune system. Each node is endowed with a bit-string…

Disordered Systems and Neural Networks · Physics 2015-03-19 Elena Agliari , Lorenzo Asti , Adriano Barra , Luca Ferrucci

We consider the problem of self tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B lymphocytes of the same idiotype which is encoded by a bit string. The links of the…

Cell Behavior · Quantitative Biology 2013-08-30 Robert Schulz , Benjamin Werner , Ulrich Behn

We present a model for the evolution of networks of occupied sites on undirected regular graphs. At every iteration step in a parallel update I randomly chosen empty sites are occupied and occupied sites having degree outside of a given…

Statistical Mechanics · Physics 2009-11-07 M. Brede , U. Behn

We develop a modular mean field theory for a minimalistic model of the idiotypic network. The model comprises the random influx of new idiotypes and a deterministic selection. It describes the evolution of the idiotypic network towards…

Cell Behavior · Quantitative Biology 2015-06-03 Holger Schmidtchen , Ulrich Behn

In this work we use belief-propagation techniques to study the equilibrium behaviour of a minimal model for the immune system comprising interacting T and B clones. We investigate the effect of the so-called idiotypic interactions among…

Disordered Systems and Neural Networks · Physics 2016-08-24 Silvia Bartolucci , Alexander Mozeika , Alessia Annibale

Divergence in antigen response of the immune network is discussed, based on shape-space modelling. The present model extends the shape-space model by introducing the evolution of specificity of idiotypes. When the amount of external antigen…

chao-dyn · Physics 2007-05-23 K. Harada , T. Ikegami

In spite of their many facets, the phenomena of autoimmunity and immunodeficiency seem to be related to each other through the subtle links connecting retroviral mutation and action to immune response and adaptation. In a previous work, we…

Populations and Evolution · Quantitative Biology 2016-07-01 Valmir C. Barbosa , Raul Donangelo , Sergio R. Souza

We investigate the onset of the discontinuous percolation transition in small-world hyperbolic networks by studying the systems-size scaling of the typical largest cluster approaching the transition, $p\nearrow p_{c}$. To this end, we…

Statistical Mechanics · Physics 2014-08-01 Vijay Singh , Stefan Boettcher

We numerically study a dynamical system model of an idiotypic immune network with a small number of degrees of freedom. The model was originally introduced by Varela et.al., and describes antibodies interacting in a body in order to prepare…

Chaotic Dynamics · Physics 2009-10-31 Satoko Itaya , Tatsuya Uezu

Percolation theory can be used to describe the structural properties of complex networks using the generating function formulation. This mapping assumes that the network is locally tree-like and does not contain short-range loops between…

Physics and Society · Physics 2021-02-03 Peter Mann , V. Anne Smith , John B. O. Mitchell , Simon Dobson

We present a unifying, consistent, finite-size-scaling picture for percolation theory bringing it into the framework of a general, renormalization-group-based, scaling scheme for systems above their upper critical dimensions $d_c$.…

Statistical Mechanics · Physics 2017-05-16 Ralph Kenna , Bertrand Berche

Majority bootstrap percolation is a model of infection spreading in networks. Starting with a set of initially infected vertices, new vertices become infected once half of their neighbours are infected. Balogh, Bollob\'{a}s and Morris…

Combinatorics · Mathematics 2025-07-10 Maurício Collares , Joshua Erde , Anna Geisler , Mihyun Kang

In this paper we study the small-world network model of Watts and Strogatz, which mimics some aspects of the structure of networks of social interactions. We argue that there is one non-trivial length-scale in the model, analogous to the…

Statistical Mechanics · Physics 2009-10-31 M. E. J. Newman , D. J. Watts

The immune system protects the body against health-threatening entities, known as antigens, through very complex interactions involving the antigens and the system's own entities. One remarkable feature resulting from such interactions is…

Cell Behavior · Quantitative Biology 2007-05-23 L. E. Flores , E. J. Aguilar , V. C. Barbosa , L. A. V. de Carvalho

A quasispecies is the stationary state of a set of interrelated genotypes that evolve according to the usual principles of selection and mutation. Quasispecies studies have invariably concentrated on the possibility of errors during…

Populations and Evolution · Quantitative Biology 2015-01-20 Valmir C. Barbosa , Raul Donangelo , Sergio R. Souza

We consider cumulative merging percolation (CMP), a long-range percolation process describing the iterative merging of clusters in networks, depending on their mass and mutual distance. For a specific class of CMP processes, which…

Statistical Mechanics · Physics 2020-05-07 Claudio Castellano , Romualdo Pastor-Satorras

We present simulation results for the contact process on regular, cubic networks that are composed of a one-dimensional lattice and a set of long edges with unbounded length. Networks with different sets of long edges are considered, that…

Statistical Mechanics · Physics 2015-05-13 R. Juhász , G. Ódor

We present a comprehensive and versatile theoretical framework to study site and bond percolation on clustered and correlated random graphs. Our contribution can be summarized in three main points. (i) We introduce a set of iterative…

Statistical Mechanics · Physics 2015-12-16 Antoine Allard , Laurent Hébert-Dufresne , Jean-Gabriel Young , Louis J. Dubé
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