Organization and evolution of synthetic idiotypic networks
Abstract
We introduce a class of weighted graphs whose properties are meant to mimic the topological features of idiotypic networks, namely the interaction networks involving the B-core of the immune system. Each node is endowed with a bit-string representing the idiotypic specificity of the corresponding B cell and a proper distance between any couple of bit-strings provides the coupling strength between the two nodes. We show that a biased distribution of the entries in bit-strings can yield fringes in the (weighted) degree distribution, small-worlds features, and scaling laws, in agreement with experimental findings. We also investigate the role of ageing, thought of as a progressive increase in the degree of bias in bit-strings, and we show that it can possibly induce mild percolation phenomena, which are investigated too.
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Cite
@article{arxiv.1112.2066,
title = {Organization and evolution of synthetic idiotypic networks},
author = {Elena Agliari and Lorenzo Asti and Adriano Barra and Luca Ferrucci},
journal= {arXiv preprint arXiv:1112.2066},
year = {2015}
}
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13 pages