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We study a dynamical system model of an idiotypic immune network with a small number of degrees of freedom, mainly focusing on the effect of a threshold above which antibodies can recognise antibodies. The response of the system to…

Condensed Matter · Physics 2009-11-07 Satoko Itaya , Tatsuya Uezu

T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding how T cell receptors (TCRs) discriminate…

Molecular Networks · Quantitative Biology 2025-11-25 François X. P. Bourassa , Sooraj Achar , Grégoire Altan-Bonnet , Paul François

The search for patterns or motifs in data represents an area of key interest to many researchers. In this paper we present the Motif Tracking Algorithm, a novel immune inspired pattern identification tool that is able to identify variable…

Artificial Intelligence · Computer Science 2010-07-05 William Wilson , Phil Birkin , Uwe Aickelin

The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to the pathogenic environment to reduce the cost of infections. We develop a general…

Populations and Evolution · Quantitative Biology 2016-02-17 Andreas Mayer , Vijay Balasubramanian , Thierry Mora , Aleksandra M. Walczak

Anomaly detection systems need to consider a lot of information when scanning for anomalies. One example is the context of the process in which an anomaly might occur, because anomalies for one process might not be anomalies for a different…

Machine Learning · Computer Science 2021-01-18 Sebastian Eresheim , Lukas Daniel Klausner , Patrick Kochberger

In this paper we outline initial concepts for an immune inspired algorithm to evaluate price time series data. The proposed solution evolves a short term pool of trackers dynamically through a process of proliferation and mutation, with…

Artificial Intelligence · Computer Science 2010-07-05 William Wilson , Phil Birkin , Uwe Aickelin

Associative network models featuring multi-tasking properties have been introduced recently and studied in the low load regime, where the number $P$ of simultaneously retrievable patterns scales with the number $N$ of nodes as $P\sim \log…

Disordered Systems and Neural Networks · Physics 2013-03-01 Elena Agliari , Alessia Annibale , Adriano Barra , A. C. C. Coolen , Daniele Tantari

Recently it has been demonstrated that causal entropic forces can lead to the emergence of complex phenomena associated with human cognitive niche such as tool use and social cooperation. Here I show that even more fundamental traits…

Information Theory · Computer Science 2016-04-20 Fouad Khan

Microbiological systems evolve to fulfill their tasks with maximal efficiency. The immune system is a remarkable example, where self-non self distinction is accomplished by means of molecular interaction between self proteins and antigens,…

Cell Behavior · Quantitative Biology 2013-08-26 Marcio Argollo de Menezes , Edgardo Brigatti , Veit Schwämmle

Biological systems, from cells to organisms, must respond to the ever changing environment in order to survive and function. This is not a simple task given the often random nature of the signals they receive, as well as the intrinsically…

Quantitative Methods · Quantitative Biology 2015-07-09 Aleksandra M. Walczak

A contextual anomaly detection method is proposed and applied to the physical motions of a robot swarm executing a coverage task. Using simulations of a swarm's normal behavior, a normalizing flow is trained to predict the likelihood of a…

Robotics · Computer Science 2025-11-25 Ingeborg Wenger , Peter Eberhard , Henrik Ebel

In this paper, after a telegraphic introduction to modern immunology, we present a simple model for the idiotypic network among antibodies and we study its relevance for the maintenance of immunological memory. We also consider the problem…

Condensed Matter · Physics 2008-02-03 Giorgio Parisi

The adaptive immune system of vertebrates can detect, respond to, and memorize diverse pathogens from past experience. While the clonal selection of T helper (Th) cells is the simple and established mechanism to better recognize new…

Populations and Evolution · Quantitative Biology 2021-03-17 Takuya Kato , Tetsuya J. Kobayashi

This paper presents HURRA, a system that aims to reduce the time spent by human operators in the process of network troubleshooting. To do so, it comprises two modules that are plugged after any anomaly detection algorithm: (i) a first…

Artificial Intelligence · Computer Science 2021-07-26 Jose M. Navarro , Dario Rossi

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Cellular bioelectricity describes the biological phenomenon in which cells in living tissue generate and maintain patterns of voltage gradients induced by differing concentrations of charged ions. A growing body of research suggests that…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-09-27 Seth Gilbert , James Maguire , Calvin Newport

Anomalies represent deviations from the intended system operation and can lead to decreased efficiency as well as partial or complete system failure. As the causes of anomalies are often unknown due to complex system dynamics, efficient…

Machine Learning · Computer Science 2021-08-31 Benjamin Lindemann , Benjamin Maschler , Nada Sahlab , Michael Weyrich

The mammalian adaptive immune system has evolved over millions of years to become an incredibly effective defense against foreign antigens. The adaptive immune system's humoral response creates plasma B cells and memory B cells, each with…

Cell Behavior · Quantitative Biology 2021-06-21 Stephen Lindsly , Maya Gupta , Cooper Stansbury , Indika Rajapakse

Nonlinear coupling between inter- and intra-element dynamics appears as a collective behaviour of elements. The elements in this paper denote symptoms such as a bacterium having an internal network of genes and proteins, a reactive droplet,…

Physics and Society · Physics 2013-05-29 Dan Tanaka

The Dendritic Cell Algorithm (DCA) as one of the emerging evolutionary algorithms is based on the behavior of the specific immune agents; known as Dendritic Cells (DCs). DCA has several potentially beneficial features for binary…

Cryptography and Security · Computer Science 2020-04-22 Ehsan Farzadnia , Hossein Shirazi , Alireza Nowroozi