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Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity. The application of rational design engineering methods promise to make this more efficient, faster, cheaper…

Molecular Networks · Quantitative Biology 2021-08-18 Robyn P. Araujo , Sean T. Vittadello , Michael P. H. Stumpf

Scientific discovery can be framed as a thermodynamic process in which an agent invests physical work to acquire information about an environment under a finite work budget. Using established results about the thermodynamics of computing,…

Information Theory · Computer Science 2025-11-20 Mihir Rao

Machine learning models are increasingly trained or fine-tuned on synthetic data. Recursively training on such data has been observed to significantly degrade performance in a wide range of tasks, often characterized by a progressive drift…

Machine Learning · Statistics 2026-02-19 Nail B. Khelifa , Richard E. Turner , Ramji Venkataramanan

We wish to minimize the resources used for network coding while achieving the desired throughput in a multicast scenario. We employ evolutionary approaches, based on a genetic algorithm, that avoid the computational complexity that makes…

Networking and Internet Architecture · Computer Science 2016-11-15 Minkyu Kim , Muriel Medard , Varun Aggarwal , Una-May O'Reilly , Wonsik Kim , Chang Wook Ahn , Michelle Effros

The paper describes multistage design of composite (modular) systems (i.e., design of a system trajectory). This design process consists of the following: (i) definition of a set of time/logical points; (ii) modular design of the system for…

Artificial Intelligence · Computer Science 2013-06-20 Mark Sh. Levin

Understanding how the time-complexity of evolutionary algorithms (EAs) depend on their parameter settings and characteristics of fitness landscapes is a fundamental problem in evolutionary computation. Most rigorous results were derived…

Neural and Evolutionary Computing · Computer Science 2016-10-28 Dogan Corus , Duc-Cuong Dang , Anton V. Eremeev , Per Kristian Lehre

In recent years, many design automation methods have been developed to routinely create approximate implementations of circuits and programs that show excellent trade-offs between the quality of output and required resources. This paper…

Neural and Evolutionary Computing · Computer Science 2021-08-17 Lukas Sekanina

Search-based Software Engineering has been utilized for a number of software engineering activities. One area where Search-Based Software Engineering has seen much application is test data generation. Evolutionary testing designates the use…

Software Engineering · Computer Science 2011-03-02 P. Maragathavalli

Measures of information transfer have become a popular approach to analyze interactions in complex systems such as the Earth or the human brain from measured time series. Recent work has focused on causal definitions of information transfer…

Methodology · Statistics 2016-03-21 Jakob Runge

Learning is a fundamental characteristic of living systems, enabling them to comprehend their environments and make informed decisions. These decision-making processes are inherently influenced by available information about their…

Disordered Systems and Neural Networks · Physics 2025-04-21 Arnab Barua , Haralampos Hatzikirou , Sumiyoshi Abe

We examine the evolution of expression patterns and the organization of genetic information in populations of self-replicating digital organisms. Seeding the experiments with a linearly expressed ancestor, we witness the development of…

adap-org · Physics 2007-05-23 Charles Ofria , Christoph Adami

As a result of a hundred million years of evolution, living animals have adapted extremely well to their ecological niche. Such adaptation implies species-specific interactions with their immediate environment by processing sensory cues and…

Disordered Systems and Neural Networks · Physics 2022-04-28 Tom Birkoben , Hermann Kohlstedt

Data analysis in modern science using extensive experimental and observational facilities, such as a gravitational wave detector, is essential in the search for novel scientific discoveries. Accordingly, various techniques and mathematical…

Instrumentation and Methods for Astrophysics · Physics 2022-06-14 Piljong Jung , Sang Hoon Oh , Young-Min Kim , Edwin J. Son , John J. Oh

We introduce the diffusion and superposition distances as two metrics to compare signals supported in the nodes of a network. Both metrics consider the given vectors as initial temperature distributions and diffuse heat trough the edges of…

Social and Information Networks · Computer Science 2014-12-01 Santiago Segarra , Weiyu Huang , Alejandro Ribeiro

We propose that genetic encoding of self-assembling components greatly enhances the evolution of complex systems and provides an efficient platform for inductive generalization, i.e. the inductive derivation of a solution to a problem with…

Populations and Evolution · Quantitative Biology 2007-05-23 Rudolf M. Fuechslin , Thomas Maeke , Uwe Tangen , John S. McCaskill

A novel optimization strategy, Info-Evo, is described, in which natural gradient search using nonparametric Fisher information is used to provide ongoing guidance to an evolutionary learning algorithm, so that the evolutionary process…

Neural and Evolutionary Computing · Computer Science 2021-03-09 Ben Goertzel

At the heart of path-planning methods for autonomous robotic exploration is a heuristic which encourages exploring unknown regions of the environment. Such heuristics are typically computed using frontier-based or information-theoretic…

Robotics · Computer Science 2020-11-11 Di Deng , Runlin Duan , Jiahong Liu , Kuangjie Sheng , Kenji Shimada

Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes. We discuss how to…

Quantitative Methods · Quantitative Biology 2016-11-15 Andrew W. Eckford , Kenneth A. Loparo , Peter J. Thomas

We consider approaches for controlling the buildup of noise by design of gates for chemical and biomolecular computing, in order to realize stable, scalable networks for multi-step information processing. Solvable rate-equation models are…

Biological Physics · Physics 2011-02-28 Vladimir Privman

Information theory is gaining popularity as a tool to characterize performance of biological systems. However, information is commonly quantified without reference to whether or how a system could extract and use it; as a result,…

Molecular Networks · Quantitative Biology 2016-11-28 Mikhail Tikhonov , Shawn C. Little , Thomas Gregor