Related papers: A Bit-String Model for Biological Aging
Bi-clustering is a useful approach in analyzing biological data when observations come from heterogeneous groups and have a large number of features. We outline a general Bayesian approach in tackling bi-clustering problems in moderate to…
This paper aims to develop practical applications of the model for the highly technical measure-valued populations developed by the authors in \cite{FanEtal20}. We consider the problem of estimation of parameters in the general age and…
Systems Biology has emerged in the last years as a new holistic approach based on the global understanding of cells instead of only being focused on their individual parts (genes or proteins), to better understand the complexity of human…
Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources. The use of mathematical models allows researchers to perform…
Machines provide a longstanding model for how organisms accumulate damage, age, and die. However, the large-scale observation and analysis of complex machine populations under real-world conditions is routinely missing from this framework.…
We propose a new stochastic model for biological neural nets which is a continuous time version of the model proposed by Galves and L\"ocherbach in [A. Galves and E. L\"ocherbach, "Infinite systems of interacting chains with memory of…
One issue in aging is how to stimulate the cognitive skills of older adults. One way to address it is the use of serious games delivered through humanoid robots, to provide engaging ways to perform exercises to train memory, attention,…
We consider a simple model of a structural glass, represented by a lattice gas with kinetic constraints in contact with a particle reservoir. Quench below the glass transition is represented by the jump of the chemical potential above a…
A formulation of bit-string models of language evolution, based on differential equations for the population speaking each language, is introduced and preliminarily studied. Connections with replicator dynamics and diffusion processes are…
As computer scientists working in bioinformatics/computational biology, we often face the challenge of coming up with an algorithm to answer a biological question. This occurs in many areas, such as variant calling, alignment, and assembly.…
This study develops a methodology by capturing both the battery aging state and degradation rate for improved life prediction performance. The aging state is indicated by six physical features of an equivalent circuit model that are…
``The purpose of life is to obtain knowledge, use it to live with as much satisfaction as possible, and pass it on with improvements and modifications to the next generation.'' This may sound philosophical, and the interpretation of words…
Mathematical modelling is a cornerstone of computational biology. While mechanistic models might describe the interactions of interest of a system, they are often difficult to study. On the other hand, abstract models might capture key…
The possible coexistence of one host, one aggressive parasite and one non-lethal parasite is simulated using the Penna model of biological ageing. If the aggressive parasites survive the difficult initial times where they have to adjust…
I present a simple numerical model based on iteratively updating subgroups of a population, individually modeled by nonnegative real numbers, by a constant decay factor; however, at each iteration, one group is selected to instead be…
We consider a 13-dimensional age-structured discrete red coral population model varying with respect to a fitness parameter. Our numerical results give a bifurcation diagram of both equilibria and stable invariant curves of orbits. We…
The performance of automated face recognition systems is inevitably impacted by the facial aging process. However, high quality datasets of individuals collected over several years are typically small in scale. In this work, we propose,…
For many applications of agent-based models (ABMs), an agent's age influences important decisions (e.g. their contribution to/withdrawal from pension funds, their level of risk aversion in decision-making, etc.) and outcomes in their life…
In this paper, we introduce a general numerical method to approximate the reproduction numbers of a large class of multi-group, age-structured, population models with a finite age span. To provide complete flexibility in the definition of…
In this note, we focus on a selection model problem: a mono-exponential model versus a bi-exponential one. This is done in the biological context of living cells, where small data are available. Classical statistics are revisited to improve…