Related papers: A Bit-String Model for Biological Aging
To explore the mechanistic relationships between ageing, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network. Each node can be either damaged (i.e.…
Determining the properties of old stellar populations (those with age >1 Gyr) has long involved the comparison of their integrated light, either in the form of photometry or spectroscopic indexes, with empirical or synthetic templates. Here…
Social evolutionary theory seeks to explain increases in the scale and complexity of human societies, from origins to present. Over the course of the twentieth century, social evolutionary theory largely fell out of favor as a way of…
We consider an age-size structured cell population model based on the cell cycle length. The model is described by a first order partial differential equation with initial-boundary conditions. Using the theory of semigroups of positive…
This paper introduces a comprehensive model for age estimation, verification, and comparability, offering a comprehensive solution for a wide range of applications. It employs advanced learning techniques to understand age distribution and…
Modeling and simulation are recognized as important aspects of the scientific method for more than 70 years but its adoption in biology has been slow. Debates on its representativeness, usefulness, and whether the effort spent on such…
Branching processes are models used to describe populations that reproduce and die over time. In the classical setting, an individual's reproductive capacity remains constant throughout its lifetime. However, in real-world situations,…
The current understanding of aging phenomena is mainly confined to the study of systems with short-ranged interactions. Little is known about the aging of long-ranged systems. Here, the aging in the phase-ordering kinetics of the…
The concept of biological age (BA), although important in clinical practice, is hard to grasp mainly due to the lack of a clearly defined reference standard. For specific applications, especially in pediatrics, medical image data are used…
In 1995 T.J.Penna introduced a simple model of biological aging. A modified Penna model has been demonstrated to exhibit behaviour of real-life systems including catastrophic senescence in salmon and a mortality plateau at advanced ages. We…
We describe a 3D percolation-type approach to modeling of the processes of aging and certain other properties of tissues analyzed as systems consisting of interacting cells. Lattice sites are designated as regular (healthy) cells, senescent…
Online genealogy datasets contain extensive information about millions of people and their past and present family connections. This vast amount of data can assist in identifying various patterns in human population. In this study, we…
With the rise of computers, simulation models have emerged beside the more traditional statistical and mathematical models as a third pillar for ecological analysis. Broadly speaking, a simulation model is an algorithm, typically…
Age estimation from images can be used in many practical scenes. Most of the previous works targeted on the estimation from images in which only one face exists. Also, most of the open datasets for age estimation contain images like that.…
The evolutionary biology of aging is fundamental to understanding the mechanisms of aging and how to develop anti-aging treatments. Thus far most evolutionary theory concerns the genetics of aging with limited physiological integration.…
The death of a biological population is an extreme event which we investigate here for a host-parasitoid system. Our simulations using the Penna ageing model show how biological evolution can ``teach'' the parasitoids to avoid extinction by…
In these lecture notes I describe some of the main theoretical ideas emerged to explain the aging dynamics. This is meant to be a very short introduction to aging dynamics and no previous knowledge is assumed. I will go through simple…
We employ the framework of multitype Galton-Watson processes to model a population of dividing cells. The cellular type is represented by its biological age, defined as the count of harmful proteins hosted by the cell. The stochastic…
Many insurance products and pension plans provide benefits which are related to couples, and thus under influence of the survival status of two lives. Some studies show the future lifetime of couples is correlated. Three reasons are…
Biological systems, from a cell to the human brain, are inherently complex. A powerful representation of such systems, described by an intricate web of relationships across multiple scales, is provided by complex networks. Recently, several…