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We study the folding of RNA secondary structures with quenched sequence randomness by means of the constrained annealing method. A thermodynamic phase transition is induced by including the conformational weight of loop structures. In…

Biological Physics · Physics 2020-02-05 Flavio Iannelli , Yevgeni Mamasakhlisov , Roland R. Netz

Statistical thermodynamics basis of energy and residue position fluctuations is explained for native proteins. The protein and its surroundings are treated as a canonical system with emphasis on the effects of energy exchange between the…

Biological Physics · Physics 2015-05-28 Burak Erman

An 1d model with time-dependent random hopping is proposed to describe charge transport in DNA. It admits to investigate both diffusion of electrons and their tunneling between different sites in DNA. The tunneling appears to be strongly…

Soft Condensed Matter · Physics 2009-11-07 E. I. Kats , V. V. Lebedev

The speed of site-specific binding of transcription factor (TFs) proteins with genomic DNA seems to be strongly retarded by the randomly occurring sequence traps. Traps are those DNA sequences sharing significant similarity with the…

Subcellular Processes · Quantitative Biology 2016-07-22 G. Niranjani , R. Murugan

We find that the conditional statistics of temperature difference at fixed values of the locally averaged temperature dissipation rate in turbulent convection become Gaussian in the regime where the mixing dynamics is expected to be driven…

Statistical Mechanics · Physics 2009-11-07 Emily S. C. Ching , K. L. Chau

A formal analogy of fluctuating diffusivity to thermodynamics is discussed for messenger RNA molecules fluorescently fused to a protein in living cells. Regarding the average value of the fluctuating diffusivity of such RNA-protein…

Statistical Mechanics · Physics 2021-03-17 Yuichi Itto

We examine the elastic model of short circular DNA. We obtain analytic expressions for configurations, elastic energy, twist and linking number of our solutions. We find the onset of the plectonemic transition. We suggest ways to use our…

Soft Condensed Matter · Physics 2008-02-03 Boris Fain , Joseph Rudnick

We study the effect of thermal fluctuations on the critical dynamics of the three-dimensional disordered superconductor across the normal-superconducting transition. We employ a phenomenological hydrodynamic approach, and in particular find…

Superconductivity · Physics 2009-10-31 Smitha Vishveshwara , Matthew P. A. Fisher

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

Biological Physics · Physics 2018-10-02 Hervé Turlier , Timo Betz

We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and…

Biomolecules · Quantitative Biology 2009-11-13 Tobias Ambjornsson , Suman K. Banik , Oleg Krichevsky , Ralf Metzler

To survive environmental conditions, cells transcribe their response activities into encoded mRNA sequences in order to produce certain amounts of protein concentrations. The external conditions are mapped into the cell through the…

Biological Physics · Physics 2017-10-26 Andrés F. López-Lopera , Mauricio A. Álvarez

We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to…

Biological Physics · Physics 2010-01-27 B. S. Alexandrov , V. Gelev , A. R. Bishop , A. Usheva , K. O. Rasmussen

This contribution presents a review of our present theoretical as well as experimental knowledge of different fluctuation observables relevant to nuclear multifragmentation. The possible connection between the presence of a fluctuation peak…

Nuclear Experiment · Physics 2009-11-11 F. Gulminelli , M. D'Agostino

Charge transport through a short DNA oligomer (Dickerson dodecamer) in presence of structural fluctuations is investigated using a hybrid computational methodology based on a combination of quantum mechanical electronic structure…

Soft Condensed Matter · Physics 2015-05-14 R. Gutierrez , R. Caetano , P. B. Woiczikowski , T. Kubar , M. Elstner , G. Cuniberti

This work addresses a longstanding theoretical discrepancy using Density Functional Theory (DFT) with experimental observations of CO binding trends on electrocatalytically relevant metals for the CO2 reduction reaction (CO2RR). By…

DNA regulation and repair processes require direct interactions between proteins and DNA at specific sites. Local fluctuations of the sugar-phosphate backbones and bases of DNA (a form of DNA "breathing") play a central role in such…

The absorption of ultraviolet light creates excitations in DNA, which subsequently start moving in the helix. Their fate is important for an understanding of photo damage, and is determined by the interplay of electronic couplings between…

Chemical Physics · Physics 2015-05-18 Arend G. Dijkstra , Yoshitaka Tanimura

We characterize the equilibrium thermodynamics of a thick polymer confined in a spherical region of space. This is used to gain insight into the DNA packaging process. The experimental reference system for the present study is the recent…

Statistical Mechanics · Physics 2007-05-23 Davide Marenduzzo , Cristian Micheletti

DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of…

Quantitative Methods · Quantitative Biology 2012-02-03 Jens Karschau , J. Julian Blow , Alessandro P. S. de Moura

Within the nucleus, structural maintenance of chromosome protein complexes, namely condensin and cohesin, create an architecture to facilitate the organization and proper function of the genome. Condensin, in addition to performing loop…

Biological Physics · Physics 2024-07-01 Anna Coletti , Benjamin Walker , Kerry Bloom , Katherine Newhall