Optimal Placement of Origins for DNA Replication
Quantitative Methods
2012-02-03 v1 Statistical Mechanics
Biological Physics
Subcellular Processes
Abstract
DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyse these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.
Keywords
Cite
@article{arxiv.1202.0433,
title = {Optimal Placement of Origins for DNA Replication},
author = {Jens Karschau and J. Julian Blow and Alessandro P. S. de Moura},
journal= {arXiv preprint arXiv:1202.0433},
year = {2012}
}
Comments
5 pages, 3 figures