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Pattern formation and the mechanics of a mixture of actin filaments and myosin motors that is confined by a rigid membrane is investigated. By using a coarse-grained molecular dynamics model, we demonstrate that the competition between the…

Soft Condensed Matter · Physics 2023-04-12 Mitsusuke Tarama , Tatsuo Shibata

The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton…

We consider a model of active Brownian particles with velocity-alignment in two spatial dimensions with passive and active fluctuations. Hereby, active fluctuations refers to purely non-equilibrium stochastic forces correlated with the…

Statistical Mechanics · Physics 2016-05-02 Robert Grossmann , Lutz Schimansky-Geier , Pawel Romanczuk

We present a model study of gliding assays in which actin filaments are moved by non-processive myosin motors. We show that even if the power stroke of the motor protein has no lateral component, the filaments will rotate around their axis…

Biological Physics · Physics 2009-08-18 Andrej Vilfan

F1F0 ATP synthase (ATPase) either facilitates the synthesis of ATP in the mitochondrial membranes and bacterial inner membranes in a process driven by the proton moving force (pmf), or uses the energy from ATP hydrolysis to pump protons…

Subcellular Processes · Quantitative Biology 2016-07-12 O. Kulish , A. D. Wright , E. M. Terentjev

In recent years, several artificial molecular motors driven and controlled by electric currents have been proposed. Similar to Brownian machines, these systems work by turning random inelastic tunneling events into a directional rotation of…

Mesoscale and Nanoscale Physics · Physics 2022-10-31 Federico D. Ribetto , Sebastián E. Deghi , Hernán L. Calvo , Raúl A. Bustos-Marún

Living cells move thanks to assemblies of actin filaments and myosin motors that range from very organized striated muscle tissue to disordered intracellular bundles. The mechanisms powering these disordered structures are debated, and all…

Biological Physics · Physics 2017-09-26 Martin Lenz

In this paper, we develop and analyze a minimal model for a 2D network of cross-linked actin filaments and myosin motors, representing the cortical cytoskeleton of eukaryotic cells. We implement coarse-grained representations of force…

Subcellular Processes · Quantitative Biology 2016-12-23 William M. McFadden , Patrick M. McCall , Edwin M. Munro

Here we study a pumping device capable of maintaining a density gradient and a flux of particles across a membrane. Its driving mechanism is based on the flashing ratchet effect powered by the random telegraph process in the presence of…

Statistical Mechanics · Physics 2015-05-13 A. Gomez-Marin , J. M. Sancho

In contrast to equilibrium systems, inertia can profoundly impact the phase behavior of active systems. This has been made particularly evident in recent years, with motility-induced phase separation (MIPS) exhibiting several intriguing…

Soft Condensed Matter · Physics 2025-04-21 Jiechao Feng , Ahmad K. Omar

A Brownian Motor is a nanoscale or molecular device that combines the effects of thermal noise, spatial or temporal asymmetry, and directionless input energy to drive directed motion. Because of the input energy, Brownian motors function…

Statistical Mechanics · Physics 2009-11-13 R. Dean Astumian

The efficiency of different types of Brownian motors is calculated analytically and numerically. We find that motors based on flashing ratchets present a low efficiency and an unavoidable entropy production. On the other hand, a certain…

Statistical Mechanics · Physics 2009-10-31 J. M. R. Parrondo , J. M. Blanco , F. J. Cao , R. Brito

Many biological processes involve the action of molecular motors that interact with the cell cytoskeleton. Some processes, such as the transport of cargoes is achieved mainly by the action of individual motors. Other, such as cell motility…

Biological Physics · Physics 2011-03-25 Oded Farago , Anne Bernheim-Groswasser

Motor enzymes catalyze chemical reactions, like the hydrolysis of ATP, and in the process they also perform work. Recent studies indicate that motor enzymes perform work with specific intermediate steps in their catalyzed reactions,…

Biological Physics · Physics 2007-05-23 Josh E. Baker

We report the study of a new experimental granular Brownian motor, inspired to the one published in [Phys. Rev. Lett. 104, 248001 (2010)], but different in some ingredients. As in that previous work, the motor is constituted by a rotating…

Statistical Mechanics · Physics 2014-03-18 Andrea Gnoli , Alessandro Sarracino , Alberto Petri , Andrea Puglisi

We present a model for a thermal Brownian motor based on Feynman's famous ratchet and pawl device. Its main feature is that the ratchet and the pawl are in different thermal baths and connected by an harmonic spring. We simulate its…

Other Condensed Matter · Physics 2009-11-11 A. Gomez-Marin , J. M. Sancho

Molecular motors belonging to the kinesin and myosin super family hydrolyze ATP by cycling through a sequence of chemical states. These cytoplasmic motors are dimers made up of two linked identical monomeric globular proteins. Fueled by the…

Biological Physics · Physics 2022-12-28 Ryota Takaki , Mauro L. Mugnai , D. Thirumalai

We model the dynamics of a processive or rotary molecular motor using a renewal processes, in line with the work initiated by Svoboda, Mitra and Block. We apply a functional technique to compute different types of multiple-time correlation…

Statistical Mechanics · Physics 2007-05-23 Jaime E. Santos , Thomas Franosch , Andrea Parmeggiani , Erwin Frey

Living systems at the molecular scale are composed of many constituents with strong and heterogeneous interactions, operating far from equilibrium, and subject to strong fluctuations. These conditions pose significant challenges to…

Statistical Mechanics · Physics 2023-04-11 Emma Lathouwers , Joseph N. E. Lucero , David A. Sivak

The active Brownian particle (ABP) model describes a swimmer, synthetic or living, whose direction of swimming is a Brownian motion. The swimming is due to a propulsion force, and the fluctuations are typically thermal in origin. We present…

Soft Condensed Matter · Physics 2022-07-18 Jean-Luc Thiffeault , Jiajia Guo