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Quantitatively mapping three-dimensional (3D) flow, diffusion, and particle density in crowded living cells remains challenging because most dynamic optical microscopy measurements are effectively planar and existing analysis methods…

Quantitative Methods · Quantitative Biology 2026-03-31 Ahmad Mahmood , Paul W. Wiseman

Photonic integrated circuits (PICs) play a pivotal role in many applications. Particularly powerful are circuits based on meshes of reconfigurable Mach-Zehnder interferometers as they enable active processing of light. Various possibilities…

The need for solving optimization problems is prevalent in a wide range of physical applications, including neuroscience, network design, biological systems, socio-economics, and chemical reactions. Many of these are classified as…

We describe a new spatio-temporal video autoencoder, based on a classic spatial image autoencoder and a novel nested temporal autoencoder. The temporal encoder is represented by a differentiable visual memory composed of convolutional long…

Machine Learning · Computer Science 2016-09-02 Viorica Patraucean , Ankur Handa , Roberto Cipolla

A novel method nicknamed ELASTIC is proposed for the alignment of multiple-aperture telescopes, in particular segmented telescopes. It only needs the acquisition of two diversity images of an unresolved source, and is based on the…

Instrumentation and Methods for Astrophysics · Physics 2017-08-02 S. Vievard , F. Cassaing , L. M. Mugnier

Quantifying the number of molecules from fluorescence microscopy measurements is an important topic in cell biology and medical research. In this work, we present a consecutive algorithm for super-resolution (STED) scanning microscopy that…

Applications · Statistics 2023-10-03 Katharina Proksch , Frank Werner , Jan Keller-Findeisen , Haisen Ta , Axel Munk

Fluid-structure interaction in the developing heart is an active area of research in developmental biology. However, investigation of heart dynamics is mostly limited to computational fluid dynamics simulations using heart wall structure…

Quantitative Methods · Quantitative Biology 2018-03-01 Vytautas Zickus , Jonathan M. Taylor

Integrated optics are used to achieve astronomical interferometry inside robust and compact materials, improving the instruments stability and sensitivity. In order to perform differential phase measurements at the H$\alpha$ line (656.3 nm)…

We present a new approach for constructing optical phase-space-time-frequency tomography (OPSTFT) of an optical wave field. This tomography can be measured by using a novel four-window optical imaging system based on two local oscillator…

Quantum Physics · Physics 2015-05-27 Paul Rojas , Rachel Blaser , Yong Meng Sua , Kim Fook Lee

Multiplexed immunofluorescence microscopy captures detailed measurements of spatially resolved, multiple biomarkers simultaneously, revealing tissue composition and cellular interactions in situ among single cells. The growing scale and…

Software Engineering · Computer Science 2025-06-03 Fang Liu , Rui He , Andrei Bombin , Ahmad B. Abdallah , Omar Eldaghar , Tommy R. Sheeley , Sam E. Ying , George Zaki

The rapid growth of artificial intelligence, coupled with the slowing of Moore's law, is straining computing infrastructure, as CMOS electronics face inherent limits in bandwidth, energy efficiency, and parallelism. Integrated photonic…

Integrated photonic devices have become pivotal elements across most research fields that involve light-based applications. A particularly versatile category of this technology are programmable photonic integrated processors, which are…

Photonic integrated circuits offer a compact and stable platform for generating, manipulating, and detecting light. They are instrumental for classical and quantum applications. Imperfections stemming from fabrication constraints,…

Analog photonic solutions offer unique opportunities to address complex computational tasks with unprecedented performance in terms of energy dissipation and speeds, overcoming current limitations of modern computing architectures based on…

Challenges such as the lack of high-quality annotations, long-tailed data distributions, and inconsistent staining styles pose significant obstacles to training neural networks to detect abnormal cells in cytopathology robustly. This paper…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Qiuyi Qi , Xin Li , Ming Kong , Zikang Xu , Bingdi Chen , Qiang Zhu , S Kevin Zhou

As photonic technologies continue to grow in multidimensional aspects, integrated photonics holds a unique position and continuously presents enormous possibilities to research communities. Applications span across data centers,…

Recently developed methods for rapid continuous volumetric two-photon microscopy facilitate the observation of neuronal activity in hundreds of individual neurons and changes in blood flow in adjacent blood vessels across a large volume of…

Image and Video Processing · Electrical Eng. & Systems 2020-01-16 Shir Gur , Lior Wolf , Lior Golgher , Pablo Blinder

Integrated photonics offers great potential for quantum communication devices in terms of complexity, robustness and scalability. Silicon photonics in particular is a leading platform for quantum photonic technologies, with further benefits…

Photonic integrated circuits have been extensively explored for optical processing with the aim of breaking the speed bottleneck of digital electronics. However, the input/output (IO) bottleneck remains one of the key barriers. Here we…

Emerging Technologies · Computer Science 2024-05-24 Minjia Chen , Yizhi Wang , Chunhui Yao , Adrian Wonfor , Shuai Yang , Richard Penty , Qixiang Cheng

Based on the particle-in-cell (PIC) plasma simulation method, the speed-limited PIC (SLPIC) method delivers faster kinetic plasma simulation in cases where the particle distributions evolve slowly compared with the maximum stable PIC…

Computational Physics · Physics 2019-01-09 Gregory R. Werner , Thomas G. Jenkins , Andrew M. Chap , John R. Cary