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Predicting the relationship between a molecule's structure and its odor remains a difficult, decades-old task. This problem, termed quantitative structure-odor relationship (QSOR) modeling, is an important challenge in chemistry, impacting…

Identifying molecules from mass spectrometry (MS) data remains a fundamental challenge due to the semantic gap between physical spectral peaks and underlying chemical structures. Existing deep learning approaches often treat spectral…

Machine Learning · Computer Science 2026-02-03 Seunghyun Yoo , Sanghong Kim , Namkyung Yoon , Hwangnam Kim

Olfaction lies at the intersection of chemical structure, neural encoding, and linguistic perception, yet existing representation methods fail to fully capture this pathway. Current approaches typically model only isolated segments of the…

Computation and Language · Computer Science 2026-04-21 Yanyi Su , Hongshuai Wang , Zhifeng Gao , Jun Cheng

Spatiotemporal learning is challenging due to the intricate interplay between spatial and temporal dependencies, the high dimensionality of the data, and scalability constraints. These challenges are further amplified in scientific domains,…

Machine Learning · Computer Science 2025-04-17 David Keetae Park , Xihaier Luo , Guang Zhao , Seungjun Lee , Miruna Oprescu , Shinjae Yoo

The coupling of an electron monochromator (EM) to a mass spectrometer (MS) has created a new analytical technique, EM-MS, for the investigation of electrophilic compounds. This method provides a powerful tool for molecular identification of…

When confronted with a substance of unknown identity, researchers often perform mass spectrometry on the sample and compare the observed spectrum to a library of previously-collected spectra to identify the molecule. While popular, this…

Chemical Physics · Physics 2019-05-07 Jennifer N. Wei , David Belanger , Ryan P. Adams , D. Sculley

Mass spectrometry (MS) plays a critical role in molecular identification, significantly advancing scientific discovery. However, structure elucidation from MS data remains challenging due to the scarcity of annotated spectra. While…

Machine Learning · Computer Science 2025-10-24 Yang Han , Pengyu Wang , Kai Yu , Xin Chen , Lu Chen

Mass spectrometry, especially so-called tandem mass spectrometry, is commonly used to assess the chemical diversity of samples. The resulting mass fragmentation spectra are representations of molecules of which the structure may have not…

Machine Learning · Computer Science 2025-02-18 Niek de Jonge , Justin J. J. van der Hooft , Daniel Probst

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

While visual and auditory information conveyed by wavelength of light and frequency of sound have been decoded, predicting olfactory information encoded by the combination of odorants remains challenging due to the unknown and potentially…

Machine Learning · Computer Science 2023-05-23 Mengji Zhang , Yusuke Hiki , Akira Funahashi , Tetsuya J. Kobayashi

We propose spatial semantic embedding network (SSEN), a simple, yet efficient algorithm for 3D instance segmentation using deep metric learning. The raw 3D reconstruction of an indoor environment suffers from occlusions, noise, and is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Dongsu Zhang , Junha Chun , Sang Kyun Cha , Young Min Kim

Electrochemical impedance spectroscopy (EIS) is an effective method for studying the electrochemical systems. The interpretation of EIS is the biggest challenge in this technology, which requires reasonable modeling. However, the modeling…

Data Analysis, Statistics and Probability · Physics 2019-07-04 Shan Zhu , Xinyang Sun , Yuxuan Wang , Naiqin Zhao , Junwei Sha

This study introduces a novel approach, combining substruct counting, $k$-mers, and Daylight-like fingerprints, to expand the representation of chemical structures in SMILES strings. The integrated method generates comprehensive molecular…

Biomolecules · Quantitative Biology 2024-04-01 Sarwan Ali , Prakash Chourasia , Murray Patterson

Segmenting object instances is a key task in machine perception, with safety-critical applications in robotics and autonomous driving. We introduce a novel approach to instance segmentation that jointly leverages measurements from multiple…

Computer Vision and Pattern Recognition · Computer Science 2022-10-18 Alex Zihao Zhu , Vincent Casser , Reza Mahjourian , Henrik Kretzschmar , Sören Pirk

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

Neurons and Cognition · Quantitative Biology 2024-04-09 Vivek Agarwal , Joshua Harvey , Dmitry Rinberg , Vasant Dhar

The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throughput elucidation of…

Understanding the relationship between atomic structure (order) and chemical composition (chemistry) is critical for advancing materials science, yet traditional spectroscopic techniques can be slow and damaging to sensitive samples.…

Materials Science · Physics 2025-08-29 Mridul Kumar , Yevgeny Rakita

The vibrational theory of olfaction was posited to explain subtle effects in the sense of smell inexplicable by models in which molecular structure alone determines an odorant's smell. Amazingly, behavioral and neurophysiological evidence…

Biological Physics · Physics 2019-05-01 Nishattasnim Liza , Enrique P. Blair

X-ray Photoelectron Spectroscopy (XPS) is a crucial technique for material surface analysis, yet interpreting its spectra is often challenging for both human analysts and automated methods due to the prevalence of variable spectral shifts…

Materials Science · Physics 2026-03-06 Issa Saddiq , Yuxin Fan , Robert G. Palgrave , Mark A. Isaacs , David Morgan , Keith T. Butler

The combination of Transformer-based encoders with contrastive learning represents the current mainstream paradigm for sentence representation learning. This paradigm is typically based on the hidden states of the last Transformer block of…

Computation and Language · Computer Science 2025-08-26 Jianxiang Zang , Nijia Mo , Yonda Wei , Meiling Ning , Hui Liu
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