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Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution…

Populations and Evolution · Quantitative Biology 2015-06-12 Armita Nourmohammad , Stephan Schiffels , Michael Laessig

Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current…

Molecular Networks · Quantitative Biology 2015-02-11 Brandon Barker , Lin Xu , Zhenglong Gu

It is well-known that population structure is a catalyst for the evolution of cooperation since individuals can reciprocate with their neighbors through local interactions defined by network structures. Previous research typically relies on…

Physics and Society · Physics 2021-12-16 Anzhi Sheng , Aming Li , Long Wang

We investigate evolutionary dynamics of two-strategy matrix games with zealots in finite populations. Zealots are assumed to take either strategy regardless of the fitness. When the strategy selected by the zealots is the same, the fixation…

Populations and Evolution · Quantitative Biology 2016-03-18 Yohei Nakajima , Naoki Masuda

We consider the Moran process, as generalized by Lieberman, Hauert and Nowak (Nature, 433:312--316, 2005). A population resides on the vertices of a finite, connected, undirected graph and, at each time step, an individual is chosen at…

Computational Complexity · Computer Science 2014-03-21 Josep Díaz , Leslie Ann Goldberg , George B. Mertzios , David Richerby , Maria Serna , Paul G. Spirakis

Phenotypically structured equations arise in population biology to describe the interaction of species with their environment that brings the nutrients. This interaction usually leads to selection of the fittest individuals. Models used in…

Analysis of PDEs · Mathematics 2015-06-18 Alexander Lorz , Benoit Perthame

We study fixation probabilities for the Moran stochastic process for the evolution of a population with three or more types of individuals and frequency-dependent fitnesses. Contrarily to the case of populations with two types of…

Populations and Evolution · Quantitative Biology 2018-11-26 Eliza M. Ferreira , Armando G. M. Neves

Biodiversity and extinction are central issues in evolution. Dynamical balance among different species in ecosystems is often described by deterministic replicator equations with moderate success. However, fluctuations are inevitable,…

Populations and Evolution · Quantitative Biology 2014-11-25 Tsung-Cheng Lu , Yi-Ko Chen , Hsiu-Hau Lin , Chun-Chung-Chen

We study the adaptation dynamics of an initially maladapted asexual population with genotypes represented by binary sequences of length $L$. The population evolves in a maximally rugged fitness landscape with a large number of local optima.…

Populations and Evolution · Quantitative Biology 2007-05-23 Kavita Jain , Joachim Krug

Fixation probabilities are essential for characterizing stochastic evolutionary dynamics, but analytical results remain limited mainly to systems with two competing types. We develop a perturbative framework to compute fixation…

Populations and Evolution · Quantitative Biology 2026-04-15 Ian Braga , Lucas Wardil , Ricardo Martinez-Garcia

Stochastic chemical reaction or population dynamics in finite systems often terminates in an absorbing state. Yet in large spatially extended systems, the time to reach species extinction (or fixation) becomes exceedingly long. Tuning…

Populations and Evolution · Quantitative Biology 2025-11-17 Kenneth A. V. Distefano , Sara Shabani , Uwe C. Täuber

We study fixation in large, but finite, populations with two types, and dynamics governed by birth-death processes. By considering a restricted class of such processes, we derive a continuous approximation for the probability of fixation…

Populations and Evolution · Quantitative Biology 2016-02-02 Fabio A. C. C. Chalub , Max O. Souza

Existing theoretical models of evolution focus on the relative fitness advantages of different mutants in a population while the dynamic behavior of the population size is mostly left unconsidered. We here present a generic stochastic model…

Populations and Evolution · Quantitative Biology 2010-10-20 Anna Melbinger , Jonas Cremer , Erwin Frey

We discuss a model for evolutionary game dynamics in a growing, network-structured population. In our model, new players can either make connections to random preexisting players or preferentially attach to those that have been successful…

Physics and Society · Physics 2015-05-13 J. Poncela , J. Gomez-Gardenes , A. Traulsen , Y. Moreno

In contrast to the neutral population cycles of the deterministic mean-field Lotka--Volterra rate equations, including spatial structure and stochastic noise in models for predator-prey interactions yields complex spatio-temporal structures…

Populations and Evolution · Quantitative Biology 2013-10-16 Ulrich Dobramysl , Uwe C. Tauber

The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise. Selection by individuals' fitness, usually the basic driving…

Populations and Evolution · Quantitative Biology 2009-09-26 Jonas Cremer , Tobias Reichenbach , Erwin Frey

Our understanding of evolution is shaped strongly by how we conceive of its fundamental causes. In the original Modern Synthesis, evolution was defined as a process of shifting the frequencies of available alleles at many loci affecting a…

Populations and Evolution · Quantitative Biology 2018-05-17 Arlin Stoltzfus

Population structure affects the outcome of natural selection. Static population structures can be described by graphs, where individuals occupy the nodes, and interactions occur along the edges. General conditions for evolutionary success…

Populations and Evolution · Quantitative Biology 2020-01-08 Benjamin Allen , Gabor Lippner , Martin A. Nowak

We consider a biological population in which a beneficial mutation is undergoing a selective sweep when a second beneficial mutation arises at a linked locus and we investigate the probability that both mutations will eventually fix in the…

Probability · Mathematics 2008-12-02 Feng Yu , Alison Etheridge , Charles Cuthbertson

The accumulation of beneficial mutations on many competing genetic backgrounds in rapidly adapting populations has a striking impact on evolutionary dynamics. This effect, known as clonal interference, causes erratic fluctuations in the…

Populations and Evolution · Quantitative Biology 2013-05-31 Katya Kosheleva , Michael Desai