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The mRNA optimization is critical for therapeutic and biotechnological applications, since sequence features directly govern protein expression levels and efficacy. However, current methods face significant challenges in simultaneously…

Quantitative Methods · Quantitative Biology 2025-06-02 Zheng Gong , Ziyi Jiang , Weihao Gao , Deng Zhuo , Lan Ma

Direct Preference Optimization (DPO) has emerged as an effective approach for aligning large language models (LLMs) with human preferences. However, its performance is highly dependent on the quality of the underlying human preference data.…

Machine Learning · Computer Science 2026-03-10 Zixuan Huang , Yikun Ban , Lean Fu , Xiaojie Li , Zhongxiang Dai , Jianxin Li , Deqing Wang

The emergence of generative models enables the creation of texts and images tailored to users' preferences. Existing personalized generative models have two critical limitations: lacking a dedicated paradigm for accurate preference…

Information Retrieval · Computer Science 2026-04-23 Yuting Zhang , Ying Sun , Dazhong Shen , Ziwei Xie , Feng Liu , Changwang Zhang , Xiang Liu , Jun Wang , Hui Xiong

Aligning text-to-video diffusion models with human preferences is crucial for generating high-quality videos. Existing Direct Preference Otimization (DPO) methods rely on multi-sample ranking and task-specific critic models, which is…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Zitong Huang , Kaidong Zhang , Yukang Ding , Chao Gao , Rui Ding , Ying Chen , Wangmeng Zuo

Direct Preference Optimization (DPO) has been proposed as an effective and efficient alternative to reinforcement learning from human feedback (RLHF). In this paper, we propose a novel and enhanced version of DPO based on curriculum…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Nicu Sebe , Mubarak Shah

The rapid development of large language model (LLM) alignment algorithms has resulted in a complex and fragmented landscape, with limited clarity on the effectiveness of different methods and their inter-connections. This paper introduces…

Despite the efficacy of Direct Preference Optimization (DPO) in aligning Large Language Models (LLMs), reward hacking remains a pivotal challenge. This issue emerges when LLMs excessively reduce the probability of rejected completions to…

Computation and Language · Computer Science 2025-08-26 Chenxu Yang , Ruipeng Jia , Mingyu Zheng , Naibin Gu , Zheng Lin , Siyuan Chen , Weichong Yin , Hua Wu , Weiping Wang

Multi-modal large language models (MLLMs) are expected to support multi-turn queries of interchanging image and text modalities in production. However, the current MLLMs trained with visual-question-answering (VQA) datasets could suffer…

Computation and Language · Computer Science 2024-11-06 Shengzhi Li , Rongyu Lin , Shichao Pei

Protein sequence design must balance designability, defined as the ability to recover a target backbone, with multiple, often competing, developability properties such as solubility, thermostability, and expression. Existing approaches…

Machine Learning · Computer Science 2026-03-11 Xiaoyang Hou , Junqi Liu , Chence Shi , Xin Liu , Zhi Yang , Jian Tang

Recent progress in generative diffusion models has greatly advanced text-to-video generation. While text-to-video models trained on large-scale, diverse datasets can produce varied outputs, these generations often deviate from user…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Runtao Liu , Haoyu Wu , Zheng Ziqiang , Chen Wei , Yingqing He , Renjie Pi , Qifeng Chen

The rapidly increasing capabilities of large language models (LLMs) raise an urgent need to align AI systems with diverse human preferences to simultaneously enhance their usefulness and safety, despite the often conflicting nature of these…

Machine Learning · Computer Science 2024-03-06 Zixuan Liu , Xiaolin Sun , Zizhan Zheng

Reinforcement Learning from Human Feedback (RLHF) has become central to aligning large language models with human values, typically by first learning a reward model from preference data which is then used to update the model with…

Artificial Intelligence · Computer Science 2025-10-20 Keertana Chidambaram , Karthik Vinary Seetharaman , Vasilis Syrgkanis

Aligning large language models (LLMs) with human preferences is essential for safe and useful LLMs. Previous works mainly adopt reinforcement learning (RLHF) and direct preference optimization (DPO) with human feedback for alignment.…

Computation and Language · Computer Science 2023-10-03 Tianci Xue , Ziqi Wang , Heng Ji

While preference optimization is crucial for improving visual generative models, how to effectively scale this paradigm remains largely unexplored. Current open-source preference datasets contain conflicting preference patterns, where…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Ming Li , Jie Wu , Justin Cui , Xiaojie Li , Rui Wang , Chen Chen

Direct preference optimization (DPO) is a successful fine-tuning strategy for aligning large language models with human preferences without the need to train a reward model or employ reinforcement learning. DPO, as originally formulated,…

Computation and Language · Computer Science 2024-06-07 Afra Amini , Tim Vieira , Ryan Cotterell

Human preference alignment is critical in building powerful and reliable large language models (LLMs). However, current methods either ignore the multi-dimensionality of human preferences (e.g. helpfulness and harmlessness) or struggle with…

Machine Learning · Computer Science 2024-10-14 Xingzhou Lou , Junge Zhang , Jian Xie , Lifeng Liu , Dong Yan , Kaiqi Huang

Neural retrieval models excel in Web search, but their training requires substantial amounts of labeled query-document pairs, which are costly to obtain. With the widespread availability of Web document collections like ClueWeb22, synthetic…

Information Retrieval · Computer Science 2025-05-27 João Coelho , Bruno Martins , João Magalhães , Chenyan Xiong

Post-training of language models, either through reinforcement learning, preference optimization or supervised finetuning, tends to sharpen the output probability distribution and reduce the diversity of generated responses. This is…

Computation and Language · Computer Science 2025-05-23 Jack Lanchantin , Angelica Chen , Shehzaad Dhuliawala , Ping Yu , Jason Weston , Sainbayar Sukhbaatar , Ilia Kulikov

Direct preference optimization (DPO), a widely adopted offline preference optimization algorithm, aims to align large language models (LLMs) with human-desired behaviors using pairwise preference data. However, the generation of the winning…

Computation and Language · Computer Science 2025-02-19 Yuxin Jiang , Bo Huang , Yufei Wang , Xingshan Zeng , Liangyou Li , Yasheng Wang , Xin Jiang , Lifeng Shang , Ruiming Tang , Wei Wang

Existing pretrained models for 3D mesh generation often suffer from data biases and produce low-quality results, while global reinforcement learning (RL) methods rely on object-level rewards that struggle to capture local structure details.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Jian Liu , Jing Xu , Song Guo , Jing Li , Jingfeng Guo , Jiaao Yu , Haohan Weng , Biwen Lei , Xianghui Yang , Zhuo Chen , Fangqi Zhu , Tao Han , Chunchao Guo