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Diffusion models have achieved promising results for Structure-Based Drug Design (SBDD). Nevertheless, high-quality protein subpocket and ligand data are relatively scarce, which hinders the models' generation capabilities. Recently, Direct…

Biomolecules · Quantitative Biology 2026-02-11 Xiwei Cheng , Xiangxin Zhou , Yuwei Yang , Yu Bao , Quanquan Gu

Direct Preference Optimization (DPO) and its variants have become the de facto standards for aligning large language models (LLMs) with human preferences or specific goals. However, DPO requires high-quality preference data and suffers from…

Machine Learning · Computer Science 2024-11-12 Zhuotong Chen , Fang Liu , Jennifer Zhu , Wanyu Du , Yanjun Qi

Protein sequence design methods have demonstrated strong performance in sequence generation for de novo protein design. However, as the training objective was sequence recovery, it does not guarantee designability--the likelihood that a…

Machine Learning · Computer Science 2025-06-03 Fanglei Xue , Andrew Kubaney , Zhichun Guo , Joseph K. Min , Ge Liu , Yi Yang , David Baker

In the field of large language models (LLMs), aligning models with the diverse preferences of users is a critical challenge. Direct Preference Optimization (DPO) has played a key role in this area. It works by using pairs of preferences…

Computation and Language · Computer Science 2024-05-29 Yueqin Yin , Zhendong Wang , Yi Gu , Hai Huang , Weizhu Chen , Mingyuan Zhou

Direct Preference Optimization (DPO) is a widely used RL-free method for aligning language models from pairwise preferences, but it models preferences over full sequences even though generation is driven by per-token decisions. Existing…

Computation and Language · Computer Science 2026-05-15 Truong Nguyen , Tien-Phat Nguyen , Linh Ngo Van , Duy Minh Ho Nguyen , Khoa D. Doan , Trung Le

A single language model, even when aligned with labelers through reinforcement learning from human feedback (RLHF), may not suit all human preferences. Recent approaches therefore prefer customization, gathering multi-dimensional feedback,…

Machine Learning · Computer Science 2024-08-20 Zhanhui Zhou , Jie Liu , Jing Shao , Xiangyu Yue , Chao Yang , Wanli Ouyang , Yu Qiao

Direct Preference Optimization (DPO) has recently emerged as a simple and effective alternative to reinforcement learning from human feedback (RLHF) for aligning large language models (LLMs) with user preferences. However, existing DPO…

Machine Learning · Computer Science 2025-10-10 Jason Bohne , Pawel Polak , David Rosenberg , Brian Bloniarz , Gary Kazantsev

Direct Preference Optimization (DPO) is a method for enhancing model performance by directly optimizing for the preferences or rankings of outcomes, instead of traditional loss functions. This approach has proven effective in aligning Large…

Machine Learning · Computer Science 2024-09-18 Ruoyu Wang , Jiachen Sun , Shaowei Hua , Quan Fang

Direct preference optimization (DPO) has shown to be an effective method for large language model (LLM) alignment. Recent works have attempted to apply DPO to multimodal scenarios but have found it challenging to achieve consistent…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Fei Wang , Wenxuan Zhou , James Y. Huang , Nan Xu , Sheng Zhang , Hoifung Poon , Muhao Chen

Direct Preference Optimization (DPO) has become a popular approach for aligning language models using pairwise preferences. However, in practical post-training pipelines, on-policy generation typically yields multiple candidate responses…

Machine Learning · Computer Science 2025-06-23 Taneesh Gupta , Rahul Madhavan , Xuchao Zhang , Nagarajan Natarajan , Chetan Bansal , Saravan Rajmohan

Recent advancements in video-audio joint generation have achieved remarkable success in semantic correspondence. However, achieving precise temporal synchronization, which requires fine-grained alignment between audio events and their…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Xin Cheng , Xihua Wang , Ying Ba , Yuyue Wang , Kaisi Guan , Yinbo Wang , Wenpu Li , Ruihua Song

Text-to-motion generation is essential for advancing the creative industry but often presents challenges in producing consistent, realistic motions. To address this, we focus on fine-tuning text-to-motion models to consistently favor…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Xiaofeng Tan , Hongsong Wang , Xin Geng , Pan Zhou

Generative AI can now synthesize strikingly realistic images from text, yet output quality remains highly sensitive to how prompts are phrased. Direct Preference Optimization (DPO) offers a lightweight, off-policy alternative to RL for…

Computation and Language · Computer Science 2025-07-30 Anas Mohamed , Azal Ahmad Khan , Xinran Wang , Ahmad Faraz Khan , Shuwen Ge , Saman Bahzad Khan , Ayaan Ahmad , Ali Anwar

Diffusion models have made substantial advances in image generation, yet models trained on large, unfiltered datasets often yield outputs misaligned with human preferences. Numerous methods have been proposed to fine-tune pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Fu-Yun Wang , Yunhao Shui , Jingtan Piao , Keqiang Sun , Hongsheng Li

With the rapid advancement of large language models (LLMs), aligning policy models with human preferences has become increasingly critical. Direct Preference Optimization (DPO) has emerged as a promising approach for alignment, acting as an…

Artificial Intelligence · Computer Science 2025-07-15 Wenyi Xiao , Zechuan Wang , Leilei Gan , Shuai Zhao , Zongrui Li , Ruirui Lei , Wanggui He , Luu Anh Tuan , Long Chen , Hao Jiang , Zhou Zhao , Fei Wu

Diffusion models have achieved state-of-the-art performance across multiple domains, with recent advancements extending their applicability to discrete data. However, aligning discrete diffusion models with task-specific preferences remains…

Machine Learning · Computer Science 2025-04-10 Umberto Borso , Davide Paglieri , Jude Wells , Tim Rocktäschel

Existing post-training techniques are broadly categorized into supervised fine-tuning (SFT) and reinforcement learning (RL) methods; the former is stable during training but suffers from limited generalization, while the latter, despite its…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Daoan Zhang , Guangchen Lan , Dong-Jun Han , Wenlin Yao , Xiaoman Pan , Hongming Zhang , Mingxiao Li , Pengcheng Chen , Yu Dong , Christopher Brinton , Jiebo Luo

Mathematical reasoning presents a significant challenge for Large Language Models (LLMs) as it requires ensuring the correctness of each reasoning step. Researchers have been strengthening the mathematical reasoning abilities of LLMs…

Machine Learning · Computer Science 2025-06-23 Yunze Lin

Automatic Radiology Report Generation (RRG) is an important topic for alleviating the substantial workload of radiologists. Existing RRG approaches rely on supervised regression based on different architectures or additional knowledge…

Machine Learning · Computer Science 2024-12-16 Ting Xiao , Lei Shi , Peng Liu , Zhe Wang , Chenjia Bai

Multi-objective preference alignment of large language models (LLMs) is critical for developing AI systems that are more configurable, personalizable, helpful, and safe. However, optimizing model outputs to satisfy diverse objectives with…

Computation and Language · Computer Science 2025-03-04 Raghav Gupta , Ryan Sullivan , Yunxuan Li , Samrat Phatale , Abhinav Rastogi