Related papers: bioETH-PRS: Confidential Polygenic Risk Scoring wi…
With the widespread adoption of medical informatics, a wealth of valuable personal health records (PHR) has been generated. Concurrently, blockchain technology has enhanced the security of medical institutions. However, these institutions…
This paper presents a study of the Poof-of-Stake (PoW) Ethereum consensus protocol, following the recent switch from Proof-of-Work (PoS) to Proof-of-Stake within Merge upgrade. The new protocol has resulted in reduced energy consumption and…
We introduce the pseudorandom quantum authentication scheme (PQAS), an efficient method for encrypting quantum states that relies solely on the existence of pseudorandom unitaries (PRUs). The scheme guarantees that for any eavesdropper with…
The rapid expansion of large-scale electronic health record (EHR) data offers unique opportunities to improve the accuracy and efficiency of clinical risk estimation. Yet, because clinical events may occur outside the recording health…
Polygenic risk scores (PRS) have recently received much attention for genetics risk prediction. While successful for the Caucasian population, the PRS based on the minority population suffer from small sample sizes, high dimensionality and…
We present a scalable framework for computing polygenic risk scores (PRS) in high-dimensional genomic settings using the recently introduced Univariate-Guided Sparse Regression (uniLasso). UniLasso is a two-stage penalized regression…
In a single secret leader election protocol (SSLE), one of the system participants is chosen and, unless it decides to reveal itself, no other participant can identify it. SSLE has a great potential in protecting blockchain consensus…
Through genome-wide association studies (GWAS), disease susceptible genetic variables can be identified by comparing the genetic data of individuals with and without a specific disease. However, the discovery of these associations poses a…
Proof of Stake (PoS) protocols rely on voting mechanisms to reach consensus on the current state. If an enhanced majority of staking nodes, also called validators, agree on a proposed block, then this block is appended to the blockchain.…
Integrating blockchain technology into healthcare systems presents a transformative approach to documenting, storing, and accessing electronic health records (EHRs). This research introduces a novel blockchain-based EHR system designed to…
Electronic health records (EHRs) linked with familial relationship data offer a unique opportunity to investigate the genetic architecture of complex phenotypes at scale. However, existing heritability and coheritability estimation methods…
We present a new approach to constructing of pseudo-random binary sequences (PRS) generators for the purpose of cryptographic data protection, secured from the perpetrator's attacks, caused by generation of masses of hardware errors and…
The global Electronic Health Record (EHR) market is growing dramatically and has already hit $31.5 billion in 2018. To safeguard the security of EHR data and privacy of patients, fine-grained information access and sharing mechanisms are…
Electronic health record (EHR)-linked biobank data hold tremendous promise for large-scale discoveries via genome-wide association study (GWAS) on diverse phenotypic traits and biomarkers routinely captured in the EHR. However,…
Homomorphic Encryption (HE) allows secure and privacy-protected computation on encrypted data without the need to decrypt it. Since Shor's algorithm rendered prime factorisation and discrete logarithm-based ciphers insecure with quantum…
Fully Homomorphic Encryption (FHE) promises the ability to compute over encrypted data without revealing sensitive contents. However, enabling high-frequency updates and statistical analysis in outsourced databases remains elusive due to…
Pseudorandom states (PRSs) are state ensembles that cannot be efficiently distinguished from Haar random states. However, the definition of PRSs has been limited to pure states and lacks robustness against noise. Here, we introduce…
This paper addresses the critical challenge of ensuring healthcare policy compliance in the context of Electronic Health Records (EHRs). Despite stringent regulations like HIPAA, significant gaps in policy compliance often remain undetected…
Decentralization is a foundational principle of permissionless blockchains, with consensus mechanisms serving a critical role in its realization. This study quantifies the decentralization of consensus mechanisms in proof-of-stake (PoS)…
Fully Homomorphic Encryption (FHE) enables privacy-preserving Transformer inference, but long-sequence encrypted Transformers quickly exceed single-GPU memory capacity because encoded weights are already large and encrypted activations grow…