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Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…

Computation and Language · Computer Science 2025-05-27 Yuxing Lu , Gecheng Fu , Wei Wu , Xukai Zhao , Sin Yee Goi , Jinzhuo Wang

Large Language Models have seen expanding application across domains, yet their effectiveness as assistive tools for scientific writing - an endeavor requiring precision, multimodal synthesis, and domain expertise - remains insufficiently…

Human-Computer Interaction · Computer Science 2026-01-28 Sanchaita Hazra , Doeun Lee , Bodhisattwa Prasad Majumder , Sachin Kumar

Question answering (QA) systems for large document collections typically use pipelines that (i) retrieve possibly relevant documents, (ii) re-rank them, (iii) rank paragraphs or other snippets of the top-ranked documents, and (iv) select…

Information Retrieval · Computer Science 2021-06-17 Dimitris Pappas , Ion Androutsopoulos

Information retrieval (IR) is essential in search engines and dialogue systems as well as natural language processing tasks such as open-domain question answering. IR serve an important function in the biomedical domain, where content and…

Information Retrieval · Computer Science 2022-01-20 Man Luo , Arindam Mitra , Tejas Gokhale , Chitta Baral

Effective biomedical literature retrieval (BLR) plays a central role in precision medicine informatics. In this paper, we propose GRAPHENE, which is a deep learning based framework for precise BLR. GRAPHENE consists of three main different…

Information Retrieval · Computer Science 2019-11-22 Sendong Zhao , Chang Su , Andrea Sboner , Fei Wang

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by retrieving relevant documents from external sources and incorporating them into the context. While it improves reliability by providing factual texts, it…

Computation and Language · Computer Science 2025-05-07 Yuqiao Tan , Shizhu He , Huanxuan Liao , Jun Zhao , Kang Liu

Pretrained language models have served as important backbones for natural language processing. Recently, in-domain pretraining has been shown to benefit various domain-specific downstream tasks. In the biomedical domain, natural language…

Computation and Language · Computer Science 2022-04-25 Hongyi Yuan , Zheng Yuan , Ruyi Gan , Jiaxing Zhang , Yutao Xie , Sheng Yu

Retrieval-Augmented Generation (RAG) systems traditionally treat retrieval and generation as separate processes, requiring explicit textual queries to connect them. This separation can limit the ability of models to generalize across…

Computation and Language · Computer Science 2025-09-19 Wenzheng Zhang , Xi Victoria Lin , Karl Stratos , Wen-tau Yih , Mingda Chen

Biomedical literature and clinical narratives pose multifaceted challenges for natural language understanding, from precise entity extraction and document synthesis to multi-step diagnostic reasoning. This study extends a unified benchmark…

Computation and Language · Computer Science 2025-10-24 Yu Hou , Zaifu Zhan , Min Zeng , Yifan Wu , Shuang Zhou , Rui Zhang

Medical vision-language models (VLMs) offer promise for clinical decision support, yet their reliability under distribution shifts remains a major concern for safe deployment. These models often learn task-agnostic correlations due to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Umaima Rahman , Raza Imam , Mohammad Yaqub , Dwarikanath Mahapatra

The availability of biomedical text data and advances in natural language processing (NLP) have made new applications in biomedical NLP possible. Language models trained or fine tuned using domain specific corpora can outperform general…

Computation and Language · Computer Science 2021-07-12 Usman Naseem , Adam G. Dunn , Matloob Khushi , Jinman Kim

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they…

Artificial Intelligence · Computer Science 2026-03-03 Shuheng Chen , Namratha Patil , Haonan Pan , Angel Hsing-Chi Hwang , Yao Du , Ruishan Liu , Jieyu Zhao

Purpose: To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights large language models (LMs) and retrieval augmented generation (RAG),…

Deep Research Agents (DRAs) generate citation-rich reports via multi-step search and synthesis, yet existing benchmarks mainly target text-only settings or short-form multimodal QA, missing end-to-end multimodal evidence use. We introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Peizhou Huang , Zixuan Zhong , Zhongwei Wan , Donghao Zhou , Samiul Alam , Xin Wang , Zexin Li , Zhihao Dou , Li Zhu , Jing Xiong , Chaofan Tao , Yan Xu , Dimitrios Dimitriadis , Tuo Zhang , Mi Zhang

Segmentation of anatomical structures and pathological regions in medical images is essential for modern clinical diagnosis, disease research, and treatment planning. While significant advancements have been made in deep learning-based…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Taha Koleilat , Hojat Asgariandehkordi , Hassan Rivaz , Yiming Xiao

Large language models (LLMs) have demonstrated strong capabilities in medical question answering; however, purely parametric models often suffer from knowledge gaps and limited factual grounding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2026-04-09 Nusrat Sultana , Abdullah Muhammad Moosa , Kazi Afzalur Rahman , Sajal Chandra Banik

Protein-Text Question Answering (QA) is crucial for interpreting biological sequences through natural language. The integration of Large Language Models (LLMs) with Retrieval-Augmented Generation (RAG) that efficiently leverages biological…

Information Retrieval · Computer Science 2026-05-19 Li Ding , Duanyu Feng , Chen Huang , Yangshuai Wang , Yang Li , Wenqiang Lei , See-Kiong Ng

Recent advancements in Large Language Models (LLMs) have significantly improved their performance across various Natural Language Processing (NLP) tasks. However, LLMs still struggle with generating non-factual responses due to limitations…

Computation and Language · Computer Science 2024-09-10 Taeho Hwang , Soyeong Jeong , Sukmin Cho , SeungYoon Han , Jong C. Park

Adverse drug reactions / events (ADR/ADE) have a major impact on patient health and health care costs. Detecting ADR's as early as possible and sharing them with regulators, pharma companies, and healthcare providers can prevent morbidity…

Computation and Language · Computer Science 2022-01-07 Hasham Ul Haq , Veysel Kocaman , David Talby

This paper proposes a medical literature summary generation method based on the BERT model to address the challenges brought by the current explosion of medical information. By fine-tuning and optimizing the BERT model, we develop an…

Computation and Language · Computer Science 2024-10-29 Jiacheng Hu , Yiru Cang , Guiran Liu , Meiqi Wang , Weijie He , Runyuan Bao