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Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

With the advent of artificial intelligence (AI), many researchers are attempting to extract structured information from document-level biomedical literature by fine-tuning large language models (LLMs). However, they face significant…

Neural and Evolutionary Computing · Computer Science 2026-02-26 Lei Zhao , Ling Kang , Quan Guo

Biomedical research papers use significantly different language and jargon when compared to typical English text, which reduces the utility of pre-trained NLP models in this domain. Meanwhile Medline, a database of biomedical abstracts,…

Machine Learning · Computer Science 2021-09-15 Justin Sybrandt , Ilya Safro

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

The abstract of a scientific paper distills the contents of the paper into a short paragraph. In the biomedical literature, it is customary to structure an abstract into discourse categories like BACKGROUND, OBJECTIVE, METHOD, RESULT, and…

Computation and Language · Computer Science 2020-05-28 Soumya Banerjee , Debarshi Kumar Sanyal , Samiran Chattopadhyay , Plaban Kumar Bhowmick , Parthapratim Das

Large language models (LLMs) have shown remarkable capabilities in Natural Language Processing (NLP), especially in domains where labeled data is scarce or expensive, such as clinical domain. However, to unlock the clinical knowledge hidden…

Computation and Language · Computer Science 2023-09-18 Sonish Sivarajkumar , Mark Kelley , Alyssa Samolyk-Mazzanti , Shyam Visweswaran , Yanshan Wang

The growing volume of biomedical scholarly document abstracts presents an increasing challenge in efficiently retrieving accurate and relevant information. To address this, we introduce a novel approach that integrates an optimized topic…

Computation and Language · Computer Science 2024-11-04 Parvez Zamil , Gollam Rabby , Md. Sadekur Rahman , Sören Auer

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Prompt learning is one of the most effective paradigms for adapting pre-trained vision-language models (VLMs) to the biomedical image classification tasks in few shot scenarios. However, most of the current prompt learning methods only used…

Computer Vision and Pattern Recognition · Computer Science 2025-05-09 Wei Peng , Kang Liu , Jianchen Hu , Meng Zhang

Deep learning algorithms are dependent on the availability of large-scale annotated clinical text datasets. The lack of such publicly available datasets is the biggest bottleneck for the development of clinical Natural Language…

Computation and Language · Computer Science 2022-03-11 Sonish Sivarajkumar , Yanshan Wang

Large language models (LLMs) are widely explored for reasoning-intensive research tasks, yet resources for testing whether they can infer scientific conclusions from structured biomedical evidence remain limited. We introduce…

Computation and Language · Computer Science 2026-04-09 Weiyue Li , Ruizhi Qian , Yi Li , Yongce Li , Yunfan Long , Jiahui Cai , Yan Luo , Mengyu Wang

Automatic medical report generation (MRG) is of great research value as it has the potential to relieve radiologists from the heavy burden of report writing. Despite recent advancements, accurate MRG remains challenging due to the need for…

Computer Vision and Pattern Recognition · Computer Science 2024-01-15 Haibo Jin , Haoxuan Che , Yi Lin , Hao Chen

Large Language Models (LLMs) demonstrate remarkable versatility in various NLP tasks but encounter distinct challenges in biomedical due to the complexities of language and data scarcity. This paper investigates LLMs application in the…

Computation and Language · Computer Science 2024-07-12 Masoud Monajatipoor , Jiaxin Yang , Joel Stremmel , Melika Emami , Fazlolah Mohaghegh , Mozhdeh Rouhsedaghat , Kai-Wei Chang

Linking (aligning) biomedical concepts across diverse data sources enables various integrative analyses, but it is challenging due to the discrepancies in concept naming conventions. Various strategies have been developed to overcome this…

Information Retrieval · Computer Science 2024-05-14 Yuzhang Xie , Jiaying Lu , Joyce Ho , Fadi Nahab , Xiao Hu , Carl Yang

Scientific diagrams are essential for communicating complex methodologies in academic papers. A natural way for researchers to specify such diagrams is through rough sketches, where text labels, connectors, and spatial arrangements express…

Artificial Intelligence · Computer Science 2026-05-28 Xinjiang Yu , Junyi Han , Zhuofan Chen , Chi Zhang , Xiangyu Fu , Jingyuan Tan , Zirui You , Yixiang Jian , Yu-Ping Wang , Chengliang Chai

Medical image segmentation is vital for clinical diagnosis, yet current deep learning methods often demand extensive expert effort, i.e., either through annotating large training datasets or providing prompts at inference time for each new…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Xingjian Li , Qifeng Wu , Adithya S. Ubaradka , Yiran Ding , Colleen Que , Runmin Jiang , Jianhua Xing , Tianyang Wang , Min Xu

Automatic generation of radiology reports seeks to reduce clinician workload while improving documentation consistency. Existing methods that adopt encoder-decoder or retrieval-augmented pipelines achieve progress in fluency but remain…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Rong Fu , Yiqing Lyu , Chunlei Meng , Muge Qi , Yabin Jin , Qi Zhao , Li Bao , Juntao Gao , Fuqian Shi , Nilanjan Dey , Wei Luo , Simon Fong

Abstracts derived from biomedical literature possess distinct domain-specific characteristics, including specialised writing styles and biomedical terminologies, which necessitate a deep understanding of the related literature. As a result,…

Computation and Language · Computer Science 2023-10-25 Chen Tang , Shun Wang , Tomas Goldsack , Chenghua Lin

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Despite the remarkable success of deep learning in medical imaging analysis, medical image segmentation remains challenging due to the scarcity of high-quality labeled images for supervision. Further, the significant domain gap between…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Hedda Cohen Indelman , Elay Dahan , Angeles M. Perez-Agosto , Carmit Shiran , Doron Shaked , Nati Daniel
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