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Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Entity recognition is a critical first step to a number of clinical NLP applications, such as entity linking and relation extraction. We present the first attempt to apply state-of-the-art entity recognition approaches on a newly released…

Computation and Language · Computer Science 2019-10-04 Kathleen C. Fraser , Isar Nejadgholi , Berry De Bruijn , Muqun Li , Astha LaPlante , Khaldoun Zine El Abidine

Across medical specialties, clinical practice is anchored in evidence-based guidelines that codify best studied diagnostic and treatment pathways. These pathways routinely fall short for the long tail of real-world care not covered by…

Models based on human-understandable concepts have received extensive attention to improve model interpretability for trustworthy artificial intelligence in the field of medical image analysis. These methods can provide convincing…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Hongmei Wang , Junlin Hou , Hao Chen

We introduce LLMD, a large language model designed to analyze a patient's medical history based on their medical records. Along with domain knowledge, LLMD is trained on a large corpus of records collected over time and across facilities,…

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

The application of Artificial Intelligence (AI) in healthcare has been revolutionary, especially with the recent advancements in transformer-based Large Language Models (LLMs). However, the task of understanding unstructured electronic…

Computation and Language · Computer Science 2023-08-08 Shivani Shekhar , Simran Tiwari , T. C. Rensink , Ramy Eskander , Wael Salloum

Semantic concepts and relations encoded in domain-specific ontologies and other medical semantic resources play a crucial role in deciphering terms in medical queries and documents. The exploitation of these resources for tackling the…

Information Retrieval · Computer Science 2020-05-19 Mohammed Maree , Israa Noor , Khaled Rabayah , Mohammed Belkhatir , Saadat M. Alhashmi

Large language models (LLMs) are widely explored for reasoning-intensive research tasks, yet resources for testing whether they can infer scientific conclusions from structured biomedical evidence remain limited. We introduce…

Computation and Language · Computer Science 2026-04-09 Weiyue Li , Ruizhi Qian , Yi Li , Yongce Li , Yunfan Long , Jiahui Cai , Yan Luo , Mengyu Wang

Extracting structured information from visual documents (Visual Information Extraction, VIE) is a cornerstone of business automation. While recent Multimodal Large Language Models (MLLMs) have shown promising capabilities, existing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-22 Yandi Wang , Libin Zhan , Ziwei Huang , Tiancheng Luo , Yuxuan Jiang , Wang Dong , Leilei Gan , Jun Chen

In this study, we aim to address the task of assertion detection when extracting medical concepts from clinical notes, a key process in clinical natural language processing (NLP). Assertion detection in clinical NLP usually involves…

Computation and Language · Computer Science 2024-02-01 Yuelyu Ji , Zeshui Yu , Yanshan Wang

Detecting evidence within the context is a key step in the process of reasoning task. Evaluating and enhancing the capabilities of LLMs in evidence detection will strengthen context-based reasoning performance. This paper proposes a…

Computation and Language · Computer Science 2024-11-12 Zhouhong Gu , Lin Zhang , Xiaoxuan Zhu , Jiangjie Chen , Wenhao Huang , Yikai Zhang , Shusen Wang , Zheyu Ye , Yan Gao , Hongwei Feng , Yanghua Xiao

Concept Bottleneck Models (CBMs) are a prominent framework for interpretable AI that map learned visual features to a set of meaningful concepts for task-specific downstream predictions. Their sequential structure enhances transparency by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Mohamed Harmanani , Bining Long , Zhuoxin Guo , Paul F. R. Wilson , Amirhossein Sabour , Minh Nguyen Nhat To , Gabor Fichtinger , Purang Abolmaesumi , Parvin Mousavi

The fundamental process of evidence extraction and synthesis in evidence-based medicine involves extracting PICO (Population, Intervention, Comparison, and Outcome) elements from biomedical literature. However, Outcomes, being the most…

Computation and Language · Computer Science 2025-06-09 Yiliang Zhou , Abigail M. Newbury , Gongbo Zhang , Betina Ross Idnay , Hao Liu , Chunhua Weng , Yifan Peng

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei

Electronic health records (EHRs) contain vast amounts of complex data, but harmonizing and processing this information remains a challenging and costly task requiring significant clinical expertise. While large language models (LLMs) have…

Computation and Language · Computer Science 2024-07-02 João Matos , Jack Gallifant , Jian Pei , A. Ian Wong

Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling…

We present LLMStructBench, a novel benchmark for evaluating Large Language Models (LLMs) on extracting structured data and generating valid JavaScript Object Notation (JSON) outputs from natural-language text. Our open dataset comprises…

Computation and Language · Computer Science 2026-02-17 Sönke Tenckhoff , Mario Koddenbrock , Erik Rodner

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

Computation and Language · Computer Science 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon

The existing methods for evaluating the medical knowledge of Large Language Models (LLMs) are largely based on atemporal examination-style benchmarks, while in reality, medical knowledge is inherently dynamic and continuously evolves as new…

Machine Learning · Computer Science 2026-05-14 Zihan Guan , Qiao Jin , Guangzhi Xiong , Fangyuan Chen , Mengxuan Hu , Qingyu Chen , Yifan Peng , Zhiyong Lu , Anil Vullikanti