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Methods for inferring average causal effects have traditionally relied on two key assumptions: (i) the intervention received by one unit cannot causally influence the outcome of another; and (ii) units can be organized into non-overlapping…

Methodology · Statistics 2019-08-23 Eric J. Tchetgen Tchetgen , Isabel Fulcher , Ilya Shpitser

Most causal inference methods focus on estimating marginal average treatment effects, but many important causal estimands depend on the joint distribution of potential outcomes, including the probability of causation and proportions…

Methodology · Statistics 2025-10-16 Zach Shahn , David Madigan

Model-based reinforcement learning is attractive for sequential decision-making because it explicitly estimates reward and transition models and then supports planning through simulated rollouts. In offline settings with hidden confounding,…

Machine Learning · Computer Science 2026-04-08 Nishanth Venkatesh , Andreas A. Malikopoulos

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of…

Methodology · Statistics 2025-07-29 Prabrisha Rakshit , Xu Shi , Eric Tchetgen Tchetgen

Evaluating graphs learned by causal discovery algorithms is difficult: The number of edges that differ between two graphs does not reflect how the graphs differ with respect to the identifying formulas they suggest for causal effects. We…

Machine Learning · Statistics 2024-07-12 Leonard Henckel , Theo Würtzen , Sebastian Weichwald

We address the common yet often-overlooked selection bias in interventional studies, where subjects are selectively enrolled into experiments. For instance, participants in a drug trial are usually patients of the relevant disease; A/B…

Machine Learning · Computer Science 2025-03-11 Haoyue Dai , Ignavier Ng , Jianle Sun , Zeyu Tang , Gongxu Luo , Xinshuai Dong , Peter Spirtes , Kun Zhang

Variational inference algorithms such as belief propagation have had tremendous impact on our ability to learn and use graphical models, and give many insights for developing or understanding exact and approximate inference. However,…

Artificial Intelligence · Computer Science 2012-10-19 Qiang Liu , Alexander T. Ihler

Learning causal relationships among a set of variables, as encoded by a directed acyclic graph, from observational data is complicated by the presence of unobserved confounders. Instrumental variables (IVs) are a popular remedy for this…

Methodology · Statistics 2025-04-17 Jing Zou , Wei Li , Wei Lin

We explore algorithms to select actions in the causal bandit setting where the learner can choose to intervene on a set of random variables related by a causal graph, and the learner sequentially chooses interventions and observes a sample…

Machine Learning · Computer Science 2023-06-14 Alan Malek , Virginia Aglietti , Silvia Chiappa

Outlying observations are frequently encountered across a wide spectrum of scientific domains, posing notable challenges to the generalizability of statistical models and the reproducibility of downstream analysis. They are identified…

Methodology · Statistics 2026-03-17 Dongliang Zhang , Masoud Asgharian , Martin A. Lindquist

Estimating causal effects has become an integral part of most applied fields. In this work we consider the violation of the classical no-interference assumption with units connected by a network. For tractability, we consider a known…

Machine Learning · Statistics 2025-03-05 Alexandre Belloni , Fei Fang , Alexander Volfovsky

We consider the problem of learning causal directed acyclic graphs from an observational joint distribution. One can use these graphs to predict the outcome of interventional experiments, from which data are often not available. We show…

Machine Learning · Statistics 2016-08-18 Jonas Peters , Joris Mooij , Dominik Janzing , Bernhard Schölkopf

We provide new results for nonparametric identification, estimation, and inference of causal effects using `proxy controls': observables that are noisy but informative proxies for unobserved confounding factors. Our analysis applies to…

Econometrics · Economics 2023-11-22 Ben Deaner

Contrasting marginal counterfactual survival curves across treatment arms is an effective and popular approach for inferring the causal effect of an intervention on a right-censored time-to-event outcome. A key challenge to drawing such…

Methodology · Statistics 2022-04-29 Andrew Ying , Yifan Cui , Eric J. Tchetgen Tchetgen

A structural causal model is made of endogenous (manifest) and exogenous (latent) variables. We show that endogenous observations induce linear constraints on the probabilities of the exogenous variables. This allows to exactly map a causal…

Artificial Intelligence · Computer Science 2020-08-04 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas

Causal inference relies on the structure of a graph, often a directed acyclic graph (DAG). Different graphs may result in different causal inference statements and different intervention distributions. To quantify such differences, we…

Machine Learning · Statistics 2016-08-18 Jonas Peters , Peter Bühlmann

Inferring causal structures from experimentation is a central task in many domains. For example, in biology, recent advances allow us to obtain single-cell expression data under multiple interventions such as drugs or gene knockouts.…

Machine Learning · Computer Science 2023-02-24 Alexander Hägele , Jonas Rothfuss , Lars Lorch , Vignesh Ram Somnath , Bernhard Schölkopf , Andreas Krause

In many real-world scenarios, such as gene knockout experiments, targeted interventions are often accompanied by unknown interventions at off-target sites. Moreover, different units can get randomly exposed to different unknown…

Machine Learning · Statistics 2022-10-10 Abhinav Kumar , Gaurav Sinha

It is known that from purely observational data, a causal DAG is identifiable only up to its Markov equivalence class, and for many ground truth DAGs, the direction of a large portion of the edges will be remained unidentified. The golden…

Machine Learning · Computer Science 2019-10-15 AmirEmad Ghassami , Saber Salehkaleybar , Negar Kiyavash

We introduce a methodology for performing parameter inference in high-dimensional, non-linear diffusion processes. We illustrate its applicability for obtaining insights into the evolution of and relationships between species, including…

Machine Learning · Statistics 2024-11-15 Nicklas Boserup , Gefan Yang , Michael Lind Severinsen , Christy Anna Hipsley , Stefan Sommer